Table 2 Subgroup analysis of overall mortality with tigecycline versus other antibiotics for treatment of bloodstram infections in controlled studies
Variables | Studies, no. (patients, no.) | Mortality of tigecycline compared with control OR (95% CI); P | Heterogeneity of studies |
|---|---|---|---|
Monotherapy vs combination | 6 (250) | 2.733 (1.533–4.873); 0.001 | X2 = 5.47, df = 5, (P = 0.361), I2 = 8.7% |
Tigecycline plus polymyxins based vs other antibiotics combination | 5 (289) | 0.680 (0.407–1.135); 0.140 | X2 = 2.88, df = 4, (P = 0.578), I2 = 0.0% |
Kp BSI | 6 (466) | 0.678 (0.457–1.006); 0.054 | X2 = 3.95, df = 5, (P = 0.556), I2 = 0.0% |
KPC-Kp BSI | 5 (398) | 0.636 (0.417–0.971); 0.036 | X2 = 3.31, df = 4, (P = 0.507), I2 = 0.0% |
Acinetobacter BSI | 3 (221) | 0.967 (0.096–9.759); 0.978 | X2 = 23.76, df = 2, (P = 0.001), I2 = 91.6% |