Table 2 Reported cases of HLH and babesiosis (Babesia microti) with our case
Author, year (Ref.) | Auerbach et al. [25] | Poisnel et al. [29] | Mecchella et al. [28] | Our case | |
|---|---|---|---|---|---|
Underlying disease | Cryptosporidium | Renal transplant | None | Amyopathic DM and ILD | None |
Medication | None | Prednisone, azathioprine | None | Rituximab/MMF/prednisone | Prednisone |
Parasitemia % | 7 | 13 | 3 | <1 | 4 |
Cytopenia (as per HLH-2004) | No | Yes | Yes | Yes | Yes |
Ferritin, ng/mL | Not reported | Not reported | 5953 | 1665 | 1316 |
Fibrinogen, mg/dL | Not reported | Not reported | Not reported | Not reported | 98 |
Bone marrow biopsy | Hemophagocytic histiocytes | Hemophagocytic histiocytes | Hemophagocytic histiocytes | Not done | Dyserythropoiesis |
LDH, units/L | 485 | 3510 | 620 | 586 | 476 |
Haptoglobin mg/dL | Not reported | <3 | Undetectable | <10 | <3 |
Splenomegaly | Yes | Asplenic | Â | Not reported | No |
Fever | Yes | Yes | Yes, value not reported | Yes, but low grade | Yes |
Coombs test | Not reported | Positive | Not reported | Negative | Negative |