Table 1 Sequential antibiotic treatments used in this study
Treatment | Antibiotic addition (h) | Abbreviation | Description | |
|---|---|---|---|---|
0 h | 8 or 12 h | |||
1 | No (0) | No (8) | CON | No first and second antibiotic addition |
2 | No (0) | 1 MIC CIP (8) | CON-CIP | No initial antibiotic addition followed by 1 MIC ciprofloxacin addition |
3 | No (0) | 1 MIC MER (8) | CON-MER | No initial antibiotic addition followed by 1 MIC meropenem addition |
4 | 1/4 MIC CIP (0) | No (12) | 1/4CIP-CON | Initial 1/4 MIC ciprofloxacin followed by no antibiotic addition |
5 | 1/4 MIC CIP (0) | 1 MIC CIP (12) | 1/4CIP-CIP | Initial 1/4 MIC ciprofloxacin followed by 1 MIC ciprofloxacin addition |
6 | 1/4 MIC CIP (0) | 1 MIC MER (12) | 1/4CIP-MER | Initial 1/4 MIC ciprofloxacin followed by 1 MIC meropenem addition |