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Table 1 Sequential antibiotic treatments used in this study

From: Assessment of antibiotic resistance in Klebsiella pneumoniae exposed to sequential in vitro antibiotic treatments

Treatment Antibiotic addition (h) Abbreviation Description
0 h 8 or 12 h
1 No (0) No (8) CON No first and second antibiotic addition
2 No (0) 1 MIC CIP (8) CON-CIP No initial antibiotic addition followed by 1 MIC ciprofloxacin addition
3 No (0) 1 MIC MER (8) CON-MER No initial antibiotic addition followed by 1 MIC meropenem addition
4 1/4 MIC CIP (0) No (12) 1/4CIP-CON Initial 1/4 MIC ciprofloxacin followed by no antibiotic addition
5 1/4 MIC CIP (0) 1 MIC CIP (12) 1/4CIP-CIP Initial 1/4 MIC ciprofloxacin followed by 1 MIC ciprofloxacin addition
6 1/4 MIC CIP (0) 1 MIC MER (12) 1/4CIP-MER Initial 1/4 MIC ciprofloxacin followed by 1 MIC meropenem addition
  1. CON, CIP, and MER denote no antibiotic addition, ciprofloxacin, and meropenem, respectively