ChikDenMaZika Syndrome: the challenge of diagnosing arboviral infections in the midst of concurrent epidemics

Table 1 Main clinical findings in the ChikDenMaZika Syndrome [3, 25]

Clinical findings	ChikDenMaZika Arboviruses
	CHIK	DEN	MA	ZIKA
Fever	+++	++++	++++	++/0^a
Myalgia/arthralgia	++++	+++	+++	++
Edema in limbs	0	0	0	++
Maculopapular rash	++	++	++	+++ ^b
Retro-ocular pain	+	++	++	++
Conjunctivitis, non-purulent	+	0	0	+++
Lymphadenopathies	++	++	+	+
Hepatomegaly	++	0	+	0
Leukopenia/thrombocytopenia	++	+++	++	0/+^c
Hemorrhages	+	+++	0	0/+^c

Italics indicates for which of the arboviruses is the highest frequency of the clinical finding
^aDepends on geography and phylogeny of the virus, in some areas patients do not present fever
^bPruriginous (mild to severe)
^cIn some cases these findings have been reported [2]

ISSN: 1476-0711