Efficacy and safety profile of linezolid in the treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis: a systematic review and meta-analysis

Table 2 Summary of the methodological quality assessment of included studies

Study No.	References	IRB approval	LZD dose indicated	Individualised treatment based on DST	Hospital admission prior to LZD treatment	DOT during treatment	Treatment success definition similar to WHO
1.	Abbate et al. [35]	Yes	Yes	Yes	NR	NR	Yes
2.	Anger et al. [36]	Yes	Yes	Yes	NR	Yes	Yes
3.	Condos et al. [37]	Yes	Yes	Yes	NR	NR	Yes
4.	De Lorenzo et al. [38]	NR	Yes	Yes	NR	NR	Yes
5.	Fortún et al. [39]	Yes	Yes	Yes	NR	Yes	Yes
6.	Koh et al. [40]	Yes	Yes	Yes	NR	Yes	Yes
7.	Koh et al. [41]	Yes	Yes	Yes	NR	NR	Yes
8.	Lee et al. [42]	Yes	Yes	Yes	Yes	Yes	No
9.	Liu et al. [43]	NR	Yes	Yes	Yes	NR	NR
10.	Migliori et al. [44]	Yes	Yes	Yes	NR	Yes	Yes
11.	Nam et al. [45]	NR	Yes	Yes	NR	NR	No
12.	Park et al. [46]	Yes	Yes	Yes	NR	NR	Yes
13.	Roongruangpitayakul et al. [47]	Yes	Yes	Yes	No	Yes	Yes
14.	Schecter et al. [48]	Yes	Yes	Yes	NR	Yes	Yes
15.	Singla et al. [49]	Yes	Yes	Yes	Yes	Yes	No
16.	Tang et al. [50]	Yes	Yes	Yes	NR	NR	NR
17.	Tang et al. [51]	Yes	Yes	Yes	NR	Yes	Yes
18.	Tse-Chang et al. [52]	NR	Yes	Yes	NR	NR	Yes
19.	Udwadia et al. [53]	Yes	Yes	Yes	No	NR	NR
20.	Villar et al. [54]	Yes	Yes	Yes	NR	NR	Yes
21.	Von der Lippe et al. [55]	Yes	Yes	Yes	Yes	Yes	No
22.	Xu et al. [56]	Yes	Yes	Yes	Yes	Yes	Yes
23.	Zhang et al. [57]	Yes	Yes	Yes	Yes	NR	Yes

ISSN: 1476-0711