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Table 3 MIC profile of AMK and comparators for isolates of P. aeruginosa

From: In vitro potency of amikacin and comparators against E. coli, K. pneumoniae and P. aeruginosa respiratory and blood isolates

Isolates Antimicrobial agent Range Modal MIC50 MIC90 %S
All isolates AMK ≤0.5–>64 4 8 16 95
n = 814 ATM ≤0.06–>64 4 8 32 67
  FEP ≤0.06–>64 2 4 32 73
  CAZ 0.125–>64 2 4 64 74
  C/T ≤0.06–>64 0.5 0.5 4 95
  CIP ≤0.015–>16 0.125 0.25 16 68
  IPM ≤0.06–>64 1 2 16 62
  MEM ≤0.06–>64 0.5 1 16 71
  TZP ≤0.25–>256 8 8 256 67
  TOB ≤0.06–>64 0.5 1 8 90
MDR+isolates AMK 0.5–>64 8 8 32 87
n = 116 ATM 0.25–>64 128 32 128 19
  FEP 2–>64 32 32 128 13
  CAZ 2–>64 128 64 128 16
  C/T 0.5–>64 1 2 32 78
  CIP 2–>64 32 16 32 11
  IPM 0.5–>64 32 16 32 11
  MEM 0.25–>64 16 16 64 17
  TZP 4–>256 256 256 512 6
  TOB 0.125–>64 1 4 128 52
MEM-R isolates AMK 0.5–>64 8 8 16 91
n = 236 ATM 0.25–>64 32 16 64 35
  FEP 1–>64 16 16 64 42
  CAZ 0.5–>64 128 16 128 47
  C/T 0.25–>64 1 1 8 89
  CIP 0.06–>16 32 4 32 35
  IPM 0.25–>64 16 16 32 11
  MEM 4–>64 16 16 32 0
  TZP 4–>256 32 32 512 36
  TOB ≤0.06–>64 1 1 64 74
FEP-R isolates AMK 0.5–>64 8 8 32 89
n = 222 ATM 0.25–>64 32 32 128 23
  FEP 16–>64 16 32 64 0
  CAZ 2–>64 128 32 128 26
  C/T 0.25–>64 1 2 8 85
  CIP 0.06–>16 32 4 32 39
  IPM 0.5–64 16 8 32 37
  MEM ≤0.06–>64 16 8 32 38
  TZP 1–>256 256 128 512 20
  TOB 0.25–>64 1 1 64 76
TZP-R isolates AMK 0.5–>64 8 8 16 91
n = 267 ATM 0.25–>64 32 32 128 27
  FEP 1–>64 16 16 64 34
  CAZ 0.5–>64 128 32 128 31
  C/T 0.25–>64 1 2 8 88
  CIP ≤0.015–>16 32 2 32 46
  IPM 0.125–>64 32 8 32 39
  MEM 0.125–>64 16 4 32 44
  TZP 32–>256 32 128 512 0
  TOB 0.25–>64 1 1 64 78
  1. AMK amikacin; ATM aztreonam; FEP cefepime; CAZ ceftazidime; C/T ceftolozane/tazobactam; CIP ciprofloxacin; IPM imipenem; MEM meropenem; TZP piperacillin/tazobactam; TOB obramycin