Phenotypic and genetic changes in the life cycle of small colony variants of Salmonella enterica serotype Typhimurium induced by streptomycin

Table 2 List of genetic changes in S. Typhimurium SCVs and revertants

Mutation^a	LT2 Position^b	Mutant strain	Mutant type	Amino acid change	Gene name	Gene product
Indel_1	4,177,676	1024_4, 4V1	Insertion: T	Frame shift	ubiE (STM3970)	Ubiquinone/menaquinone Biosynthesis C-methyltransferase UbiE
Indel_2	4,177,484:4,177,487	1024_5, 5V1	Deletion: GTTT	Frame shift	ubiE (STM3970)	Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE
Indel_3	4,177,459	5V1	Insertion: T	Frame shift	ubiE (STM3970)	Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE
SNP_1	2,480,126	4V1	SNP: G to A	F125F	STM2367	Inner membrane protein
SNP_2	3,201,008	4V1	SNP: G to A	S271L	prfB (STM3041c)	Peptide chain release factor 2

^aThe genetic changes in SCVs and revertants were compared to the wild-type parental strain by analyzing the data of whole genome sequencing
^bCorresponding position in the reference genome of S. Typhimurium, LT2 (Accession number: NC_003197.1)

ISSN: 1476-0711