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Table 1 Pharmacokinetic features of quinolones

From: Chemical structure and pharmacokinetics of novel quinolone agents represented by avarofloxacin, delafloxacin, finafloxacin, zabofloxacin and nemonoxacin

Quinolone agents

Protein binding (%)

Urinary fraction (%)

Bioavailability (%)

Cmax

(mg/L)

t1/2

(h)

Ref.

Ciprofloxacin

20–40

40–50

70

4.3

4

[6]

Levofloxacin

24–38

87

99

6.2

6–7

[6]

Sparfloxacin

45

10

92

1.1

20

[6]

Trovafloxacin

76

6

88

2.1

9.6

[6]

Moxifloxacin

50

20

90

4.5

12

[6]

Gatifloxacin

20

72

96

3.8

7.8

[6]

Avarofloxacin

65

12

65

2

14

[12]

Delafloxacin

16

n.a.

n.a.

10

12

[39]

Finafloxacin

n.a.

33

n.a.

11

10

[19]

Zabofloxacin

n.a.

n.a.

n.a.

2

8

[27]

Nemonoxacin

16

n.a.

n.a.

5

15

[40]

  1. Ref reference number
  2. Urinary fraction urinary fraction excreted unbound
  3. C max peak serum concentration
  4. t 1/2 half-life time
  5. n.a. not available