Skip to main content

Table 1 Baseline characteristics of patients infected with Clostridium difficile who had detectable toxins concentrations in their baseline stools

From: A pilot study to assess bacterial and toxin reduction in patients with Clostridium difficile infection given fidaxomicin or vancomycin

Demographic

Fidaxomicin

Vancomycin

P value

N = 7

N = 5

Age, years

68 ± 18

73 ± 12

0.87

Female, n (%)

3 (43 %)

3 (60 %)

1

Community-acquired CDIa, n (%)

4 (57 %)

2 (40 %)

1

BI/NAP1/027 strain, n (%)

5 (71 %)

2 (40 %)

1

Average unformed stool per day, n

6

6

1

Patients by bristol stool score, n (%)

0.4

 7

5 (71 %)

3 (60 %)

 6

0

1 (20 %)

 ≤5

2 (29 %)

1 (20 %)

Baseline toxin A concentration (ng/mL)

0.31 [0.31–80]

3.99 [2.32–63.47]

0.53

Baseline toxin B concentration (ng/mL)

42.2 [23.62–80]

0.31 [0.31–80]

0.43

Baseline total CFU, log10 CFU/g stool

6.05 ± 2.2

6.8 ± 0.9

0.48

Baseline spores CFU, log10 CFU/g stool

5.44 ± 1.7

5.88 ± 1.24

0.75

Baseline vegetative cells CFU, log10 CFU/g stool

4.85 ± 2.85

6.57 ± 0.9

0.3

Previous therapy within 24 h, n (%)

0.66

 Metronidazole

2 (29 %)

2 (40 %)

 Vancomycin

0

0

 Vancomycin + Metronidazole

3 (42 %)

3 (60 %)

 No therapy

2 (29 %)

0

  1. aCDI diagnosis in patients who had not been discharged from a healthcare facility in the previous 12 weeks [11]