Real-world daptomycin use across wide geographical regions: results from a pooled analysis of CORE and EU-CORE

Table 2 Primary infections and pathogens

Primary infection	Pooled data (2004–2012) N = 11,557 n (%)	Overlapping time period (2007–2009)
		CORE^a	EU-CORE^a
		N = 2827 n (%)	N = 3333 n (%)
Complicated skin and soft tissue infection	3607 (31.2)	803 (28.4)	1092 (32.8)
Bacteremia	2522 (21.8)	642 (22.7)	741 (22.2)
Endocarditis	798 (6.9)	103 (3.6)	338 (10.1)
Foreign body/prosthetic infection	988 (8.5)	217 (7.7)	294 (8.8)
Osteomyelitis (non-prosthetic and prosthetic device-related)	994 (8.6)	281 (9.9)	193 (5.8)
Uncomplicated skin and soft tissue infection	1510 (13.1)	475 (16.8)	334 (10.0)
Other^b	1138 (9.8)	306 (10.8)	341 (10.2)

Primary pathogen	Pooled data (2004–2012) N = 7912 n (%)	Overlapping time period (2007–2009)
Primary pathogen		CORE^a	EU-CORE^a
Positive culture^c		N = 2002 n (%)	N = 2240 n (%)
Staphylococcus aureus	3673 (46.4)	925 (46.2)	931 (41.6)
Methicillin-susceptible	1104 (14.0)	208 (10.4)	356 (15.9)
Methicillin-resistant	2261 (28.6)	621 (31.0)	509 (22.7)
Susceptibility unknown	308 (3.9)	96 (4.8)	66 (2.9)
CoNS	1690 (21.4)	276 (13.8)	677 (30.2)
Staphylococcus epidermidis	850 (10.7)	103 (5.1)	390 (17.4)
Staphylococcus spp.–coagulase negative	840 (10.6)	173 (8.6)	287 (12.8)
Enterococci	1380 (17.4)	495 (24.7)	255 (11.4)
Vancomycin-resistant	576 (7.2)	284 (14.2)	36 (1.0)
Enterococcus faecalis	492 (6.2)	134 (6.7)	125 (5.6)
Vancomycin-resistant	83 (1.0)	37 (0.5)	10 (0.3)
Enterococcus faecium	684 (8.6)	277 (13.8)	110 (4.9)
Vancomycin-resistant	493 (6.2)	247 (12.3)	26 (0.8)
Enterococcus spp.	204 (2.6)	84 (4.2)	20 (0.9)
Streptococci	326 (4.1)	71 (3.5)	98 (4.4)
Other^d	843 (10.7)	235 (11.7)	279 (12.5)

CoNS coagulase-negative staphylococci
^aData are from three overlapping periods: 2007–2009
^bIncludes septic arthritis, urinary tract infections/pyelonephritis, central nervous system infections, metastatic abscess, antibiotic prophylaxis (surgical and non-surgical), neutropenic fever, necrotizing fasciitis, necrotizing infections, unknown or not otherwise specified infections, and data missing
^cPercentage is calculated based on positive culture results
^dIncludes Clostridium difficile, Clostridium perfringens, Clostridium species, Corynebacterium species, Staphylococcus species coagulase not specified, Gram-positive and Gram-negative bacilli and cocci, Leuconostoc species, Peptococcus species, Peptostreptococcus species, fungi/yeast, viruses, and organisms with invalid/ambiguous pathogen code

ISSN: 1476-0711