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Table 2 Mutations observed in oprD gene of IRMS P. aeruginosa isolates

From: Characterization of Pseudomonas aeruginosa with discrepant carbapenem susceptibility profile

Micro No. Amino acid
changes
Nucleotide changes Impact on oprD loops
Deletions Positions
PA3970 T103S, K115T, F170L None None L4, L6
PA4745 S57E, N262T 180 nts
332 nts
480–660
828–1219
L2, L7, L8, L9, L15
PA5778 K115T, V436Da 3 nts
2 nts
1 nt
632–634
656–657
770, 1274, 1278, 1287, 1332
L4, L6
PA6192 S57E,S59R,I210A,N262T,A281G,R310G,G425A
“MSDNNVGYKNYG’’
to
‘‘VDSSSSYAGL’’ at position 372–383
3 nts
4 nts
1nt
1 nt (insertion)
1116–1118
1147–1150
1328
1138
L2, L7, L8, L9, L15 Loss of Porin
PA6476 S57E,S59R,I210A,N262T,A281G,R310G,E426R
“MSDNNVGYKNYG’’
to
‘‘VDSSSSYAGL’’ at position 372–383
3 nts
4 nts
1 nt (insertion)
1116–1118
1146–1149
1138
L2, L7, L8, L9, L15
PA6362 K115T, L443 W 1 nt
1nt
342
1329
L4, L6
  1. aNewly observed mutation which was not reported so far