Table 2 Mutations observed in oprD gene of IRMS P. aeruginosa isolates
From: Characterization of Pseudomonas aeruginosa with discrepant carbapenem susceptibility profile
Micro No. | Amino acid changes | Nucleotide changes | Impact on oprD loops | |
|---|---|---|---|---|
Deletions | Positions | |||
PA3970 | T103S, K115T, F170L | None | None | L4, L6 |
PA4745 | S57E, N262T | 180 nts 332 nts | 480–660 828–1219 | L2, L7, L8, L9, L15 |
PA5778 | K115T, V436Da | 3 nts 2 nts 1 nt | 632–634 656–657 770, 1274, 1278, 1287, 1332 | L4, L6 |
PA6192 | S57E,S59R,I210A,N262T,A281G,R310G,G425A “MSDNNVGYKNYG’’ to ‘‘VDSSSSYAGL’’ at position 372–383 | 3 nts 4 nts 1nt 1 nt (insertion) | 1116–1118 1147–1150 1328 1138 | L2, L7, L8, L9, L15 Loss of Porin |
PA6476 | S57E,S59R,I210A,N262T,A281G,R310G,E426R “MSDNNVGYKNYG’’ to ‘‘VDSSSSYAGL’’ at position 372–383 | 3 nts 4 nts 1 nt (insertion) | 1116–1118 1146–1149 1138 | L2, L7, L8, L9, L15 |
PA6362 | K115T, L443Â W | 1 nt 1nt | 342 1329 | L4, L6 |