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Table 3 Antimicrobial susceptibility [MIC90 (mg/L), % susceptible, % resistant] of methicillin-resistant S. aureus, methicillin-susceptible S. aureus, extended-spectrum β-lactamase-positive E. coli and K. pneumoniae and multidrug-resistant Acinetobacter spp., collected in Mexico, T.E.S.T. 2005–2012

From: Antimicrobial susceptibility trends among gram-positive and -negative clinical isolates collected between 2005 and 2012 in Mexico: results from the Tigecycline Evaluation and Surveillance Trial

Pathogen

2005–2007

2008–2012

2005–2012

MIC90

%S

%R

MIC90

%S

%R

MIC90

%S

%R

S. aureus, MRSA

n = 112

n = 349

n = 461

 Levofloxacin

32

5.4

94.6

≥64

8.0

90.8

≥64

7.4

91.8

 Linezolid

2

100

0.0

2

100

0.0

2

100

0.0

 Minocycline

0.5

100

0.0

1

97.4

1.4

1

98.0

1.1

 Tigecycline

0.25

100

–

0.5

100

–

0.5

100

–

 Vancomycin

1

100

0.0

1

100

0.0

1

100

0.0

S. aureus, MSSA

n = 182

n = 379

n = 561

 Levofloxacin

0.5

95.1

3.3

2

89.2

7.9

1

91.1

6.4

 Linezolid

4

100

0.0

4

100

0.0

4

100

0.0

 Minocycline

1

99.5

0.5

0.5

98.9

0.8

0.5

99.1

0.7

 Tigecycline

0.25

100

–

0.25

100

–

0.25

100

–

 Vancomycin

1

100

0.0

1

100

0.0

1

100

0.0

E. coli, ESBL-positive

n = 134 (43/91)

n = 333 (9/324)

n = 467 (52/415)

 Amikacin

16

94.8

0.7

32

87.7

6.3a

32

89.7

4.7

 Amoxicillin-clavulanate

32

26.1

29.1

32

16.8

40.2a

32

19.5

37.0

 Ampicillin

≥64

0.7

99.3

≥64

2.1

97.6

≥64

1.7

98.1

 Cefepime

≥64

23.9

58.2

≥64

26.1

60.7

≥64

25.5

60.0

 Ceftriaxone

≥128

0.0

98.5

≥128

3.6

95.8

≥128

2.6

96.6

 Imipenem

0.5

97.7

2.3

–

[9]

[0]

0.25

98.1

1.9

 Levofloxacin

≥16

3.0

94.8

≥16

7.8

90.7

≥16

6.4

91.9

 Meropenem

0.12

100

0.0

0.25

97.2

1.5

0.25

97.8

1.2

 Minocycline

16

70.1

17.9

≥32

47.7

36.0a

≥32

54.2

30.8

 Piperacillin-tazobactam

32

88.8

2.2

128

63.4

15.3a

128

70.7

11.6

 Tigecycline

0.5

100

0.0

0.5

100

0.0

0.5

100

0.0

K. pneumoniae, ESBL-positive

n = 59 (15/44)

n = 154

n = 213 (15/198)

 Amikacin

≥128

76.3

16.9

≥128

59.1

32.5

≥128

63.8

28.2

 Amoxicillin-clavulanate

≥64

25.4

40.7

≥64

13.6

53.9

≥64

16.9

50.2

 Ampicillin

≥64

1.7

96.6

≥64

0.0

100

≥64

0.5

99.1

 Cefepime

32

81.4

11.9

≥64

53.9

36.4a

≥64

61.5

29.6

 Ceftriaxone

≥128

3.4

91.5

≥128

0.0

98.1

≥128

0.9

96.2

 Imipenem

1

100

0.0

–

–

–

–

–

–

 Levofloxacin

≥16

45.8

49.2

≥16

44.8

51.3

≥16

45.1

50.7

 Meropenem

0.5

95.5

4.5

0.5

93.5

4.5

0.5

93.9

4.5

 Minocycline

≥32

52.5

32.2

≥32

40.3

41.6

≥32

43.7

39.0

 Piperacillin-tazobactam

≥256

49.2

25.4

≥256

37.0

37.0

≥256

40.4

33.8

 Tigecycline

2

96.6

0.0

2

94.8

0.6

2

95.3

0.5

Acinetobacter spp., MDR

n = 33 (7/26)

n = 161

n = 194 (7/187)

Amikacin

≥128

12.1

84.8

≥128

6.8

83.2

≥128

7.7

83.5

Cefepime

≥64

6.1

48.5

≥64

14.9

63.4

≥64

13.4

60.8

Ceftazidime

≥64

0.0

93.9

≥64

4.3

91.3

≥64

3.6

91.8

Ceftriaxone

≥128

0.0

100

≥128

1.9

96.3

≥128

1.5

96.9

Imipenem

–

[6]

[1]

–

–

–

–

–

–

Levofloxacin

≥16

0.0

90.9

≥16

1.2

95.7

≥16

1.0

94.8

Meropenem

16

34.6

53.8

≥32

29.8

64.6

≥32

30.5

63.1

Minocycline

2

90.9

6.1

≥32

62.1

28.6a

≥32

67.0

24.7

Piperacillin-tazobactam

≥256

9.1

84.8

≥256

3.1

92.5

≥256

4.1

91.2

  1. n values given in parentheses indicate the number of isolates tested against imipenem and meropenem, respectively
  2. When <10 isolates MIC90 data are not presented and the number of isolates susceptible or resistant are presented in parenthesis
  3. When no isolates were tested against imipenem between 2008 and 2012, imipenem data for 2005–2012 are not presented as the only data available are for the 2005–2007 period
  4. aA statistically significant change in susceptibility (p < 0.01 by the Cochran–Mantel–Haenszel test) between 2005–2007 and 2008–2012