Pathogen | 2005–2007 | 2008–2012 | 2005–2012 | ||||||
---|---|---|---|---|---|---|---|---|---|
MIC90 | %S | %R | MIC90 | %S | %R | MIC90 | %S | %R | |
S. aureus, MRSA | n = 112 | n = 349 | n = 461 | ||||||
 Levofloxacin | 32 | 5.4 | 94.6 | ≥64 | 8.0 | 90.8 | ≥64 | 7.4 | 91.8 |
 Linezolid | 2 | 100 | 0.0 | 2 | 100 | 0.0 | 2 | 100 | 0.0 |
 Minocycline | 0.5 | 100 | 0.0 | 1 | 97.4 | 1.4 | 1 | 98.0 | 1.1 |
 Tigecycline | 0.25 | 100 | – | 0.5 | 100 | – | 0.5 | 100 | – |
 Vancomycin | 1 | 100 | 0.0 | 1 | 100 | 0.0 | 1 | 100 | 0.0 |
S. aureus, MSSA | n = 182 | n = 379 | n = 561 | ||||||
 Levofloxacin | 0.5 | 95.1 | 3.3 | 2 | 89.2 | 7.9 | 1 | 91.1 | 6.4 |
 Linezolid | 4 | 100 | 0.0 | 4 | 100 | 0.0 | 4 | 100 | 0.0 |
 Minocycline | 1 | 99.5 | 0.5 | 0.5 | 98.9 | 0.8 | 0.5 | 99.1 | 0.7 |
 Tigecycline | 0.25 | 100 | – | 0.25 | 100 | – | 0.25 | 100 | – |
 Vancomycin | 1 | 100 | 0.0 | 1 | 100 | 0.0 | 1 | 100 | 0.0 |
E. coli, ESBL-positive | n = 134 (43/91) | n = 333 (9/324) | n = 467 (52/415) | ||||||
 Amikacin | 16 | 94.8 | 0.7 | 32 | 87.7 | 6.3a | 32 | 89.7 | 4.7 |
 Amoxicillin-clavulanate | 32 | 26.1 | 29.1 | 32 | 16.8 | 40.2a | 32 | 19.5 | 37.0 |
 Ampicillin | ≥64 | 0.7 | 99.3 | ≥64 | 2.1 | 97.6 | ≥64 | 1.7 | 98.1 |
 Cefepime | ≥64 | 23.9 | 58.2 | ≥64 | 26.1 | 60.7 | ≥64 | 25.5 | 60.0 |
 Ceftriaxone | ≥128 | 0.0 | 98.5 | ≥128 | 3.6 | 95.8 | ≥128 | 2.6 | 96.6 |
 Imipenem | 0.5 | 97.7 | 2.3 | – | [9] | [0] | 0.25 | 98.1 | 1.9 |
 Levofloxacin | ≥16 | 3.0 | 94.8 | ≥16 | 7.8 | 90.7 | ≥16 | 6.4 | 91.9 |
 Meropenem | 0.12 | 100 | 0.0 | 0.25 | 97.2 | 1.5 | 0.25 | 97.8 | 1.2 |
 Minocycline | 16 | 70.1 | 17.9 | ≥32 | 47.7 | 36.0a | ≥32 | 54.2 | 30.8 |
 Piperacillin-tazobactam | 32 | 88.8 | 2.2 | 128 | 63.4 | 15.3a | 128 | 70.7 | 11.6 |
 Tigecycline | 0.5 | 100 | 0.0 | 0.5 | 100 | 0.0 | 0.5 | 100 | 0.0 |
K. pneumoniae, ESBL-positive | n = 59 (15/44) | n = 154 | n = 213 (15/198) | ||||||
 Amikacin | ≥128 | 76.3 | 16.9 | ≥128 | 59.1 | 32.5 | ≥128 | 63.8 | 28.2 |
 Amoxicillin-clavulanate | ≥64 | 25.4 | 40.7 | ≥64 | 13.6 | 53.9 | ≥64 | 16.9 | 50.2 |
 Ampicillin | ≥64 | 1.7 | 96.6 | ≥64 | 0.0 | 100 | ≥64 | 0.5 | 99.1 |
 Cefepime | 32 | 81.4 | 11.9 | ≥64 | 53.9 | 36.4a | ≥64 | 61.5 | 29.6 |
 Ceftriaxone | ≥128 | 3.4 | 91.5 | ≥128 | 0.0 | 98.1 | ≥128 | 0.9 | 96.2 |
 Imipenem | 1 | 100 | 0.0 | – | – | – | – | – | – |
 Levofloxacin | ≥16 | 45.8 | 49.2 | ≥16 | 44.8 | 51.3 | ≥16 | 45.1 | 50.7 |
 Meropenem | 0.5 | 95.5 | 4.5 | 0.5 | 93.5 | 4.5 | 0.5 | 93.9 | 4.5 |
 Minocycline | ≥32 | 52.5 | 32.2 | ≥32 | 40.3 | 41.6 | ≥32 | 43.7 | 39.0 |
 Piperacillin-tazobactam | ≥256 | 49.2 | 25.4 | ≥256 | 37.0 | 37.0 | ≥256 | 40.4 | 33.8 |
 Tigecycline | 2 | 96.6 | 0.0 | 2 | 94.8 | 0.6 | 2 | 95.3 | 0.5 |
Acinetobacter spp., MDR | n = 33 (7/26) | n = 161 | n = 194 (7/187) | ||||||
Amikacin | ≥128 | 12.1 | 84.8 | ≥128 | 6.8 | 83.2 | ≥128 | 7.7 | 83.5 |
Cefepime | ≥64 | 6.1 | 48.5 | ≥64 | 14.9 | 63.4 | ≥64 | 13.4 | 60.8 |
Ceftazidime | ≥64 | 0.0 | 93.9 | ≥64 | 4.3 | 91.3 | ≥64 | 3.6 | 91.8 |
Ceftriaxone | ≥128 | 0.0 | 100 | ≥128 | 1.9 | 96.3 | ≥128 | 1.5 | 96.9 |
Imipenem | – | [6] | [1] | – | – | – | – | – | – |
Levofloxacin | ≥16 | 0.0 | 90.9 | ≥16 | 1.2 | 95.7 | ≥16 | 1.0 | 94.8 |
Meropenem | 16 | 34.6 | 53.8 | ≥32 | 29.8 | 64.6 | ≥32 | 30.5 | 63.1 |
Minocycline | 2 | 90.9 | 6.1 | ≥32 | 62.1 | 28.6a | ≥32 | 67.0 | 24.7 |
Piperacillin-tazobactam | ≥256 | 9.1 | 84.8 | ≥256 | 3.1 | 92.5 | ≥256 | 4.1 | 91.2 |