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Table 5 Antimicrobial activity of antimicrobial agents against Streptococcus spp. collected globally between 2004 - 2013

From: Global in vitro activity of tigecycline and comparator agents: Tigecycline Evaluation and Surveillance Trial 2004–2013

  MIC 90 (mg/L) MIC range (mg/L) % susceptible % resistant
Streptococcus agalactiae (n = 12,819)     
AMC 0.12 ≤0.03 – ≥ 16 - -
AMP 0.12 ≤0.06 – 0.25 100 -
CRO 0.12 ≤0.03 – 0.5 100 -
IPM (n = 2,511) 0.25 ≤0.12 – 8 - -
LVX 1 ≤0.06 – ≥ 64 98.6 1.1
LIN 1 ≤0.5 – 2 100 -
MEM (n = 10,308) ≤0.12 ≤0.12 – 1 99.9 -
MIN ≥16 ≤0.25 – ≥ 16 20.6 70.6
PEN 0.12 ≤0.06 – 0.12 100 -
TZP 0.5 ≤0.25 – ≥ 32 - -
TGC 0.12 ≤0.008 – 2 99.9 -
VAN 0.5 ≤0.12 – 1 100 -
Streptococcus pneumoniae (n = 14,562)    
AMC 2 ≤0.03 – ≥ 16 92.8 3.5
AMP 4 ≤0.06 – ≥ 32 - -
AZM (n = 12,973) 64 ≤0.03 – ≥ 128 67.2 32.4
CRO 1 ≤0.03 – ≥ 128 95.0 1.2
CLR (n = 12,973) 64 ≤0.015 – ≥ 128 67.5 32.0
CLI (n = 12,973) ≥128 ≤0.015 – ≥ 128 80.8 18.9
ERY (n = 12,973) 64 ≤0.015 – ≥ 128 66.8 32.7
IPM (n = 3,154) 0.5 ≤0.12 – ≥ 32 74.2 4.1
LVX 1 ≤0.06 – ≥ 64 98.9 0.7
LIN 1 ≤0.5 – 4 99.9 -
MEM (n = 11,408) 0.5 ≤0.12 – ≥ 32 81.4 10.0
MIN 8 ≤0.25 – ≥ 16 64.4 26.9
PEN 2 ≤0.06 – ≥ 16 61.9 14.8
TZP 2 ≤0.25 – ≥ 32 - -
TGC 0.06 ≤0.008 – 0.25 99.9 -
VAN 0.5 ≤0.12 – 1 100 -
Streptococcus pneumoniae, PRSP (n = 2,152)    
AMC 8 ≤0.03 – ≥ 16 53.2 22.7
AZM (n = 1,971) ≥128 ≤0.03 – ≥ 128 21.5 78.0
CRO 2 0.06 – ≥ 128 69.9 7.2
CLR (n = 1,971) ≥128 ≤0.015 – ≥ 128 21.8 77.8
CLI (n = 1,971) ≥128 ≤0.015 – ≥ 128 43.2 56.1
ERY (n = 1,971) ≥128 ≤0.015 – ≥ 128 20.9 78.7
IPM (n = 357) 1 ≤0.12– ≥ 32 1.4 29.7
LVX 1 ≤0.06 – ≥ 64 97.5 1.9
LIN 1 ≤0.5 – 2 100 -
MEM (n = 1,795) 1 ≤0.12 – ≥ 32 6.1 58.4
MIN ≥16 ≤0.25 – ≥ 16 27.6 60.3
TZP 8 ≤0.25 – ≥ 32 - -
TGC 0.03 ≤0.008 – 0.12 99.8 -
VAN 0.5 ≤0.12 – 1 100 -
  1. AMK, amikacin; AMC, amoxicillin-clavulanate; AMP, ampicillin; AZM, azithromycin; FEP, cefepime; CAZ, ceftazidime; CLR, clarithromycin; CLI, clindamycin; CRO, ceftriaxone; ERY, erythromycin; IPM, imipenem; LVX, levofloxacin; LZD, linezolid; MEM, meropenem; MIN, minocycline; PEN, penicillin; PRSP, penicillin-resistant S. pneumoniae; TZP, piperacillin-tazobactam; TGC, tigecycline; VAN, vancomycin; VR, vancomycin-resistant.