Table 4 Antimicrobial activity of antimicrobial agents against Enterococcus and Staphylococcus spp. collected globally between 2004 - 2013
MIC 90 (mg/L) | MIC range (mg/L) | % susceptible | % resistant | |
|---|---|---|---|---|
Enterococcus faecalis (n = 14,615) | ||||
AMC | 1 | ≤0.03 – ≥ 16 | - | - |
AMP | 2 | ≤0.06 – ≥ 32 | 99.4 | 0.6 |
CRO | ≥128 | ≤0.03 – ≥ 128 | - | - |
IPM (n = 3,208) | 4 | ≤0.12 – ≥ 32 | - | - |
LVX | ≥64 | ≤0.06 – ≥ 64 | 64.9 | 33.9 |
LIN | 2 | ≤0.5 – ≥ 16 | 99.8 | <0.1 |
MEM (n = 11,407) | 8 | ≤0.12 – ≥ 32 | - | - |
MIN | ≥16 | ≤0.25 – ≥ 16 | 34.8 | 28.2 |
PEN | 4 | ≤0.06 – ≥ 16 | 99.2 | 0.8 |
TZP | 8 | ≤0.25 – ≥ 32 | - | - |
TGC | 0.25 | ≤0.008 – 2 | 99.7 | - |
VAN | 2 | ≤0.12 – ≥ 64 | 97.5 | 2.2 |
Enterococcus faecalis, VR (n = 325) | ||||
AMC | 2 | 0.06 – ≥ 16 | - | - |
AMP | 4 | 0.12 – ≥ 32 | 94.5 | 5.5 |
CRO | ≥128 | ≤0.03 – ≥ 128 | - | - |
IPM (n = 98) | 8 | ≤0.12 – ≥ 32 | - | - |
LVX | ≥64 | 0.5 – ≥ 64 | 4.9 | 93.5 |
LIN | 2 | ≤0.5 – ≥ 16 | 98.5 | 1.2 |
MEM (n = 227) | ≥32 | ≤0.12 – ≥ 32 | - | - |
MIN | ≥16 | ≤0.25 – ≥ 16 | 44.3 | 17.8 |
PEN | 8 | 0.25 – ≥ 16 | 94.5 | 5.5 |
TZP | 16 | 0.5 – ≥ 32 | - | - |
TGC | 0.25 | ≤0.008 – 1 | 97.8 | - |
Enterococcus faecium (n = 6,167) | ||||
AMC | ≥16 | ≤0.03 – ≥ 16 | - | - |
AMP | ≥32 | ≤0.06 – ≥ 32 | 15.6 | 84.4 |
CRO | ≥128 | ≤0.03 – ≥ 128 | - | - |
IPM (n = 1,162) | ≥32 | ≤0.12 – ≥ 32 | - | - |
LVX | ≥64 | ≤0.06 – ≥ 64 | 13.1 | 83.6 |
LIN | 2 | ≤0.5 – ≥ 16 | 99.2 | 0.3 |
MEM (n = 5,005) | ≥32 | ≤0.12 – ≥ 32 | - | - |
MIN | ≥16 | ≤0.25 – ≥ 16 | 68.5 | 14.3 |
PEN | ≥16 | ≤0.06 – ≥ 16 | 15.6 | 84.4 |
TZP | ≥32 | ≤0.25 – ≥ 32 | - | - |
TGC | 0.25 | ≤0.008 – 4 | 99.7 | - |
VAN | ≥64 | ≤0.12 – ≥ 64 | 64.0 | 34.6 |
Enterococcus faecium, VR (n = 2,136) | ||||
AMC | ≥16 | ≤0.03 – ≥ 16 | - | - |
AMP | ≥32 | ≤0.06 – ≥ 32 | 1.5 | 98.5 |
CRO | ≥128 | ≤0.03 – ≥ 128 | - | - |
IPM (n = 556) | ≥32 | 0.5 – ≥ 32 | - | - |
LVX | ≥64 | 0.5 – ≥ 64 | 0.8 | 98.8 |
LIN | 2 | ≤0.5 – ≥ 16 | 98.4 | 0.7 |
MEM (n = 1,580) | ≥32 | ≤0.12 – ≥ 32 | - | - |
MIN | ≥16 | ≤0.25 – ≥ 16 | 65.0 | 13.3 |
PEN | ≥16 | ≤0.06 – ≥ 16 | 1.7 | 98.3 |
TZP | ≥32 | ≤0.25 – ≥ 32 | - | - |
TGC | 0.12 | ≤0.008 – 4 | 99.2 | - |
Staphylococcus aureus (n = 36,448) | ||||
AMC | ≥16 | ≤0.03 – ≥ 16 | - | - |
AMP | ≥32 | ≤0.06 – ≥ 32 | - | - |
CRO | ≥128 | ≤0.03 – ≥ 128 | - | - |
IPM (n = 7,302) | 16 | ≤0.12 – ≥ 32 | - | - |
LVX | 32 | ≤0.06 – ≥ 64 | 64.1 | 34.3 |
LIN | 4 | ≤0.5 – ≥ 16 | >99.9 | <0.1 |
MEM (n = 29,146) | 16 | ≤0.12 – ≥ 32 | - | - |
MIN | 0.5 | ≤0.25 – ≥ 16 | 97.3 | 0.9 |
PEN | ≥16 | ≤0.06 – ≥ 16 | 10.9 | 89.1 |
TZP | ≥32 | ≤0.25 – ≥ 32 | - | - |
TGC | 0.25 | ≤0.008 – 1 | 99.9 | - |
VAN | 1 | ≤0.12 – 4 | 100 | 0 |
Staphylococcus aureus, MRSA (n = 14,647) | ||||
AMC | ≥16 | ≤0.03 – ≥ 16 | - | - |
CRO | ≥128 | ≤0.03 – ≥ 128 | - | - |
IPM (n = 3,235) | ≥32 | ≤0.12 – ≥ 32 | - | - |
LVX | ≥64 | ≤0.06 – ≥ 64 | 22.1 | 75.9 |
LIN | 2 | ≤0.5 – ≥ 16 | 99.9 | <0.1 |
MEM (n = 11,412) | ≥32 | ≤0.12 – ≥ 32 | - | - |
MIN | 2 | ≤0.25 – ≥ 16 | 94.7 | 1.7 |
TZP | ≥32 | ≤0.25 – ≥ 32 | - | - |
TGC | 0.25 | ≤0.008 – 1 | 99.9 | - |
VAN | 1 | ≤0.12 – 4 | 99.9 | 0 |