Table 3 Antimicrobial activity of antimicrobial agents against Acinetobacter baumannii , Haemophilus influenzae and Pseudomonas aeruginosa collected globally between 2004 - 2013
MIC 90 (mg/L) | MIC range mg/L | % susceptible | % resistant | |
|---|---|---|---|---|
Acinetobacter baumannii (n = 16,778) | ||||
AMK | ≥128 | ≤0.5 – ≥ 128 | 61.1 | 32.4 |
AMC | ≥64 | ≤0.12 – ≥ 64 | - | - |
AMP | ≥64 | ≤0.5 – ≥ 64 | - | - |
FEP | ≥64 | ≤0.5 – ≥ 64 | 44.3 | 42.9 |
CAZ | ≥64 | ≤8 – ≥ 64 | 41.2 | 52.1 |
CRO | ≥128 | ≤0.06 – ≥ 128 | 23.3 | 54.6 |
IPM (n = 3,795) | ≥32 | ≤0.06 – ≥ 32 | 80.0 | 16.8 |
LVX | ≥16 | ≤0.008 – ≥ 16 | 43.0 | 46.6 |
MEM (n = 12,983) | ≥32 | ≤0.06 – ≥ 32 | 54.8 | 41.1 |
MIN | 8 | ≤0.5 – ≥ 32 | 84.5 | 5.1 |
TZP | ≥256 | ≤0.06 – ≥ 256 | 42.9 | 47.5 |
TGC | 2 | ≤0.008 – ≥ 32 | - | - |
Acinetobacter baumannii, MDR (n = 6,743) | ||||
AMK | ≥128 | ≤0.5 – ≥ 128 | 18.4 | 74.1 |
AMC | ≥64 | 1 – ≥ 64 | - | - |
AMP | ≥64 | ≤0.5 – ≥ 64 | - | - |
FEP | ≥64 | ≤0.5 – ≥ 64 | 5.5 | 80.1 |
CAZ | ≥64 | ≤8 – ≥ 64 | 4.0 | 90.8 |
CRO | ≥128 | ≤0.06 – ≥ 128 | 0.7 | 94.6 |
IPM (n = 896) | ≥32 | 0.25 – ≥ 32 | 30.9 | 64.6 |
LVX | ≥16 | 0.03 – ≥ 16 | 2.4 | 89.3 |
MEM (n = 5,847) | ≥32 | ≤0.06 – ≥ 32 | 11.9 | 84.0 |
MIN | 16 | ≤0.5 – ≥ 32 | 70.3 | 11.3 |
TZP | ≥256 | ≤0.06 – ≥ 256 | 3.0 | 90.5 |
TGC | 2 | ≤0.008 – ≥ 32 | - | - |
Haemophilus influenzae (n = 15,925) | ||||
AMK | 8 | ≤0.5 – ≥ 128 | - | - |
AMC | 1 | ≤0.12 – ≥ 64 | 99.7 | 0.3 |
AMP | 32 | ≤0.5 – ≥ 64 | 78.3 | 19.3 |
FEP | ≤0.5 | ≤0.5 – ≥ 64 | 99.5 | - |
CRO | ≤0.06 | ≤0.06 – 32 | 99.9 | - |
IPM (n = 3,672) | 1 | ≤0.06 – ≥ 32 | 99.9 | - |
LVX | 0.03 | ≤0.008 – ≥ 16 | 99.9 | - |
MEM (n = 12,253) | 0.12 | ≤0.06 – 2 | 99.9 | - |
MIN | 1 | ≤0.5 – ≥ 32 | 98.6 | 0.5 |
TZP | ≤0.06 | ≤0.06 – 64 | 99.8 | 0.2 |
TGC | 0.25 | ≤0.008 – 4 | 98.9 | - |
Haemophilus influenzae, BL-pos (n = 3,207) | ||||
AMK | 8 | ≤0.5 – ≥ 128 | - | - |
AMC | 2 | ≤0.12 – ≥ 64 | 98.9 | 1.1 |
AMP | ≥64 | ≤0.5 – ≥ 64 | 0.2 | 95.2 |
FEP | ≤0.5 | ≤0.5 – ≥ 64 | 99.1 | - |
CRO | ≤0.06 | ≤0.06 – 16 | 99.9 | - |
IPM (n = 803) | 1 | ≤0.06 – 4 | 100 | - |
LVX | 0.03 | ≤0.008 – ≥ 16 | 99.8 | - |
MEM (n = 2,404) | 0.12 | ≤0.06 – 2 | 99.8 | - |
MIN | 1 | ≤0.5 – ≥ 32 | 98.4 | 0.5 |
TZP | ≤0.06 | ≤0.06 – 64 | 99.7 | 0.3 |
TGC | 0.25 | ≤0.008 – 1 | 99.0 | - |
Pseudomonas aeruginosa (n = 28,413) | ||||
AMK | 16 | ≤0.5 – ≥ 128 | 90.2 | 6.5 |
AMC | ≥64 | ≤0.12 – ≥ 64 | - | - |
AMP | ≥64 | ≤0.5 – ≥ 64 | - | - |
FEP | 32 | ≤0.5 – ≥ 64 | 74.3 | 13.5 |
CAZ | 32 | ≤8 – ≥ 64 | 74.0 | 18.1 |
CRO | ≥128 | ≤0.06 – ≥ 128 | - | - |
IPM (n = 6,303) | 8 | ≤0.06 – ≥ 32 | 76.4 | 17.5 |
LVX | ≥16 | ≤0.008 – ≥ 16 | 63.9 | 29.5 |
MEM (n = 22,110) | 16 | ≤0.06 – ≥ 32 | 70.3 | 22.3 |
MIN | ≥32 | ≤0.5 – ≥ 32 | - | - |
TZP | 128 | ≤0.06 – ≥ 256 | 73.1 | 15.3 |
TGC | 16 | ≤0.008 – ≥ 32 | - | - |
Pseudomonas aeruginosa, MDR (n = 3,496) | ||||
AMK | ≥128 | ≤0.5 – ≥ 128 | 46.3 | 43.5 |
AMC | ≥64 | 1 – ≥ 64 | - | - |
AMP | ≥64 | ≤0.5 – ≥ 64 | - | - |
FEP | ≥64 | ≤0.5 – ≥ 64 | 8.2 | 69.0 |
CAZ | ≥64 | ≤8 – ≥ 64 | 11.7 | 77.7 |
CRO | ≥128 | 2 – ≥ 128 | - | - |
IPM (n = 557) | ≥32 | 0.5 – ≥ 32 | 5.9 | 92.1 |
LVX | ≥16 | 0.03 – ≥ 16 | 2.1 | 96.3 |
MEM (n = 2,939) | ≥32 | ≤0.06 – ≥ 32 | 4.9 | 91.8 |
MIN | ≥32 | ≤0.5 – ≥ 32 | - | - |
TZP | ≥256 | 0.25 – ≥ 256 | 10.9 | 67.7 |
TGC | ≥32 | ≤0.008 – ≥ 32 | - | - |