Table 2 Antimicrobial activity of antimicrobial agents against members of the Enterobacteriaceae collected globally between 2004 - 2013
MIC 90 (mg/L) | MIC range mg/L | % susceptible | % resistant | |
|---|---|---|---|---|
Enterobacter spp. (n = 32,987) | ||||
AMK | 4 | ≤0.5– ≥ 128 | 97.2 | 1.8 |
FEP | 8 | ≤0.5– ≥ 64 | 91.7 | 5.8 |
CRO | 64 | ≤0.06– ≥ 128 | 61.7 | 35.1 |
IPM (n = 6,963) | 1 | ≤0.06– ≥ 32 | 95.7 | 1.1 |
LVX | 8 | ≤0.008– ≥ 16 | 86.8 | 10.7 |
MEM (n = 26,024) | 0.25 | ≤0.06– ≥ 32 | 97.2 | 1.9 |
MIN | 16 | ≤0.5– ≥ 32 | 73.7 | 12.5 |
TZP | 128 | ≤0.06– ≥ 256 | 76.1 | 12.1 |
TGC | 2 | ≤0.008– ≥ 32 | 95.4 | 1.1 |
Enterobacter spp., Car-R (n = 578) | ||||
AMK | ≥128 | ≤0.5– ≥ 128 | 68.3 | 23.7 |
FEP | ≥64 | ≤0.5– ≥ 64 | 35.6 | 52.2 |
CRO | ≥128 | ≤0.06– ≥ 128 | 6.7 | 91.9 |
LVX | ≥16 | ≤0.008– ≥ 16 | 39.1 | 54.0 |
MIN | ≥32 | ≤0.5– ≥ 32 | 39.8 | 38.8 |
TZP | ≥256 | ≤0.06– ≥ 256 | 22.5 | 60.7 |
TGC | 4 | 0.06–16 | 83.0 | 5.2 |
Escherichia coli (n = 37,038) | ||||
AMK | 8 | ≤0.5– ≥ 128 | 98.3 | 0.9 |
AMC | 32 | ≤0.12– ≥ 64 | 66.6 | 14.2 |
AMP | ≥64 | ≤0.5– ≥ 64 | 35.6 | 63.5 |
FEP | 16 | ≤0.5– ≥ 64 | 88.5 | 9.0 |
CRO | 64 | ≤0.06– ≥ 128 | 79.1 | 19.9 |
IPM (n = 8,091) | 0.5 | ≤0.06– ≥ 32 | 99.4 | 0.3 |
LVX | ≥16 | ≤0.008– ≥ 16 | 66.1 | 31.5 |
MEM (n = 28,947) | ≤0.06 | ≤0.06– ≥ 32 | 99.1 | 0.5 |
MIN | 16 | ≤0.5– ≥ 32 | 77.0 | 13.0 |
TZP | 16 | ≤0.06– ≥ 256 | 91.3 | 4.4 |
TGC | 0.5 | ≤0.008– ≥ 32 | >99.9 | <0.1 |
Escherichia coli, ESBL-positive (n = 5,178) | ||||
AMK | 16 | ≤0.5– ≥ 128 | 94.2 | 2.7 |
AMC | 32 | 0.25– ≥ 64 | 31.3 | 28.5 |
AMP | ≥64 | 1– ≥ 64 | 0.4 | 99.5 |
FEP | ≥64 | ≤0.5– ≥ 64 | 32.4 | 54.8 |
CRO | ≥128 | ≤0.06– ≥ 128 | 1.3 | 97.5 |
IPM (n = 643) | 0.5 | ≤0.06–8 | 98.1 | 0.6 |
LVX | ≥16 | ≤0.008– ≥ 16 | 18.1 | 78.5 |
MEM (n = 4,535) | 0.12 | ≤0.06– ≥ 32 | 98.5 | 0.8 |
MIN | ≥32 | ≤0.5– ≥ 32 | 63.2 | 22.7 |
TZP | 64 | ≤0.06– ≥ 256 | 77.0 | 9.9 |
TGC | 0.5 | ≤0.008–8 | >99.9 | <0.1 |
Escherichia coli, Car-R (n = 181) | ||||
AMK | ≥128 | ≤0.5– ≥ 128 | 50.8 | 38.1 |
AMC | ≥64 | 2– ≥ 64 | 11.6 | 76.8 |
AMP | ≥64 | 1– ≥ 64 | 8.3 | 90.6 |
FEP | ≥64 | ≤0.5– ≥ 64 | 28.2 | 56.4 |
CRO | ≥128 | ≤0.06– ≥ 128 | 9.9 | 90.1 |
LVX | ≥16 | ≤0.008– ≥ 16 | 22.7 | 71.3 |
MIN | ≥32 | ≤0.5– ≥ 32 | 43.1 | 35.4 |
TZP | ≥256 | 1– ≥ 256 | 29.3 | 55.8 |
TGC | 2 | ≤0.008–16 | 97.2 | 1.7 |
Klebsiella oxytoca (n = 6,940) | ||||
AMK | 4 | ≤0.5– ≥ 128 | 98.8 | 0.8 |
AMC | 32 | 0.25– ≥ 64 | 79.4 | 12.4 |
FEP | 2 | ≤0.5– ≥ 64 | 96.1 | 2.4 |
CRO | 16 | ≤0.06– ≥ 128 | 81.5 | 16.2 |
IPM (n = 1,454) | 0.5 | ≤0.06– ≥ 32 | 99.2 | 0.5 |
LVX | 2 | ≤0.008– ≥ 16 | 92.1 | 5.7 |
MEM (n = 5,486) | 0.12 | ≤0.06– ≥ 32 | 98.8 | 0.8 |
MIN | 8 | ≤0.5– ≥ 32 | 88.2 | 5.6 |
TZP | ≥256 | ≤0.06– ≥ 256 | 85.1 | 12.5 |
TGC | 1 | ≤0.008–16 | 98.7 | 0.2 |
Klebsiella pneumoniae (n = 28,928) | ||||
AMK | 16 | ≤0.5– ≥ 128 | 94.4 | 3.1 |
AMC | 32 | ≤0.12– ≥ 64 | 67.9 | 20.2 |
FEP | ≥64 | ≤0.5– ≥ 64 | 81.0 | 15.8 |
CRO | ≥128 | ≤0.06– ≥ 128 | 70.1 | 28.8 |
IPM (n = 6,008) | 0.5 | ≤0.06– ≥ 32 | 97.7 | 1.6 |
LVX | ≥16 | ≤0.008– ≥ 16 | 77.4 | 19.5 |
MEM (n = 22,920) | 0.25 | ≤0.06– ≥ 32 | 93.5 | 5.4 |
MIN | 16 | ≤0.5– ≥ 32 | 71.4 | 18.0 |
TZP | ≥256 | ≤0.06– ≥ 256 | 79.4 | 14.9 |
TGC | 2 | ≤0.008– ≥ 32 | 95.3 | 0.8 |
Klebsiella pneumoniae, ESBL-positive (n = 5,899) | ||||
AMK | 32 | ≤0.5– ≥ 128 | 83.6 | 9.5 |
AMC | ≥64 | ≤0.12– ≥ 64 | 18.3 | 48.3 |
FEP | ≥64 | ≤0.5– ≥ 64 | 31.9 | 56.6 |
CRO | ≥128 | ≤0.06– ≥ 128 | 1.4 | 97.0 |
IPM (n = 946) | 1 | ≤0.06– ≥ 32 | 91.3 | 6.1 |
LVX | ≥16 | ≤0.008– ≥ 16 | 35.2 | 57.1 |
MEM (n = 4,953) | 2 | ≤0.06– ≥ 32 | 88.3 | 9.0 |
MIN | ≥32 | ≤0.5– ≥ 32 | 48.4 | 34.5 |
TZP | ≥256 | ≤0.06– ≥ 256 | 44.3 | 39.2 |
TGC | 2 | ≤0.008– ≥ 32 | 92.3 | 1.6 |
Klebsiella pneumoniae, Car-R (n = 1,330) | ||||
AMK | ≥128 | ≤0.5– ≥ 128 | 57.5 | 18.4 |
AMC | ≥64 | 1– ≥ 64 | 1.7 | 96.5 |
FEP | ≥64 | ≤0.5– ≥ 64 | 7.4 | 85.0 |
CRO | ≥128 | ≤0.06– ≥ 128 | 1.8 | 97.5 |
LVX | ≥16 | ≤0.008– ≥ 16 | 10.1 | 85.9 |
MIN | ≥32 | ≤0.5– ≥ 32 | 52.2 | 25.3 |
TZP | ≥256 | 0.12– ≥ 256 | 4.7 | 91.3 |
TGC | 2 | 0.03–16 | 92.0 | 2.1 |
Klebsiella pneumoniae, ESBL-positive, Car-R (n = 505) | ||||
AMK | ≥128 | ≤0.5– ≥ 128 | 59.8 | 15.6 |
AMC | ≥64 | 8– ≥ 64 | 0.8 | 96.2 |
FEP | ≥64 | 1– ≥ 64 | 4.8 | 83.6 |
CRO | ≥128 | 2– ≥ 128 | 0.0 | 99.6 |
LVX | ≥16 | 0.015– ≥ 16 | 6.7 | 88.5 |
MIN | ≥32 | ≤0.5– ≥ 32 | 49.7 | 28.5 |
TZP | ≥256 | 1– ≥ 256 | 2.0 | 92.9 |
TGC | 2 | 0.12–16 | 91.1 | 3.6 |
Serratia marcescens (n = 13,006) | ||||
AMK | 8 | ≤0.5– ≥ 128 | 96.5 | 2.1 |
AMC | ≥64 | ≤0.12– ≥ 64 | 3.3 | 93.9 |
AMP (n = 12,963) | ≥64 | ≤0.5– ≥ 64 | 2.7 | 88.0 |
FEP | 2 | ≤0.5– ≥ 64 | 95.2 | 3.5 |
CRO | 16 | ≤0.06– ≥ 128 | 79.6 | 16.9 |
IPM (n = 2,865) | 1 | ≤0.06–8 | 92.2 | 1.2 |
LVX | 2 | ≤0.008– ≥ 16 | 92.9 | 4.4 |
MEM (n = 10,141) | 0.25 | ≤0.06– ≥ 32 | 97.4 | 1.9 |
MIN | 8 | ≤0.5– ≥ 32 | 72.3 | 8.5 |
TZP | 16 | ≤0.06– ≥ 256 | 92.4 | 3.2 |
TGC | 2 | ≤0.008– ≥ 32 | 95.8 | 0.7 |
Serratia marcescens, Car-R (n = 229) | ||||
AMK | ≥128 | ≤0.5– ≥ 128 | 67.7 | 24.9 |
AMC | ≥64 | ≤0.12– ≥ 64 | 0.4 | 99.1 |
AMP | ≥64 | 16– ≥ 64 | 0.0 | 95.2 |
FEP | ≥64 | ≤0.5– ≥ 64 | 51.1 | 39.3 |
CRO | ≥128 | ≤0.06– ≥ 128 | 26.2 | 70.3 |
LVX | ≥16 | 0.03– ≥ 16 | 60.7 | 31.0 |
MIN | 16 | ≤0.5– ≥ 32 | 54.6 | 26.6 |
TZP | ≥256 | 0.25– ≥ 256 | 45.4 | 41.0 |
TGC | 4 | 0.12–16 | 83.8 | 4.8 |