Skip to main content
Figure 5 | Annals of Clinical Microbiology and Antimicrobials

Figure 5

From: Antifungal activity of amphotericin B and voriconazole against the biofilms and biofilm-dispersed cells of Candida albicans employing a newly developed in vitro pharmacokinetic model

Figure 5

Scanning Electron Micrograph (SEM) shows. (A) the architecture of 24 hours old biofilm of C. albicans on IV vascular catheter following continuous perfusion of the biofilm with fresh medium. (B) The dispersed cells collected from 1 milliliter effluent sample from the biofilm of C. albicans on vascular catheter following 2 day of continuous perfusion by fresh medium. (C) The dispersed cells collected from 1 milliliter effluent sample from 2-day old biofilm of C. albicans on vascular catheter following addition of 2 doses of amphotericin B at 24 hours intervals. (D) The dispersed cells collected from 1 milliliter effluent sample from 2-day old biofilm of C. albicans on vascular catheter following addition of 2 doses of voriconazole at 12 hours intervals. Note that in the biofilm, the cells exist in the yeast and the long tubular hyphal forms while the dispersed cells exist as yeast cell form only.

Back to article page