Figure 5From: Antifungal activity of amphotericin B and voriconazole against the biofilms and biofilm-dispersed cells of Candida albicans employing a newly developed in vitro pharmacokinetic model Scanning Electron Micrograph (SEM) shows. (A) the architecture of 24Â hours old biofilm of C. albicans on IV vascular catheter following continuous perfusion of the biofilm with fresh medium. (B) The dispersed cells collected from 1 milliliter effluent sample from the biofilm of C. albicans on vascular catheter following 2Â day of continuous perfusion by fresh medium. (C) The dispersed cells collected from 1 milliliter effluent sample from 2-day old biofilm of C. albicans on vascular catheter following addition of 2 doses of amphotericin B at 24Â hours intervals. (D) The dispersed cells collected from 1 milliliter effluent sample from 2-day old biofilm of C. albicans on vascular catheter following addition of 2 doses of voriconazole at 12Â hours intervals. Note that in the biofilm, the cells exist in the yeast and the long tubular hyphal forms while the dispersed cells exist as yeast cell form only.Back to article page