Table 2 Sensitivity and specificity of culture, microscopy and FISH analyses as calculated using PCR as the gold standard for the detection of C. neoformans and C. gattii in CSF
PCR | ||||
|---|---|---|---|---|
Positive | Negative | |||
Tests compared to PCR | FISH | Positive | 48 | 0 |
Negative | 0 | 64 | ||
Sensitivity (%) | 100 | |||
Specificity (%) | 100 | |||
Microscopy (Direct examination) | Positive | 46 | 0 | |
Negative | 2 | 64 | ||
Sensitivity (%) | 95.8 | |||
Specificity (%) | 100 | |||
Culture | Positive | 41 | 0 | |
Negative | 5 | 66 | ||
Sensitivity (%) | 89.1 | |||
Specificity (%) | 100 | |||