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Table 2 Sensitivity and specificity of culture, microscopy and FISH analyses as calculated using PCR as the gold standard for the detection of C. neoformans and C. gattii in CSF

From: Evaluation of fluorescence in situ hybridisation (FISH) for the detection of fungi directly from blood cultures and cerebrospinal fluid from patients with suspected invasive mycoses

  PCR
Positive Negative
Tests compared to PCR FISH Positive 48 0
Negative 0 64
Sensitivity (%) 100
Specificity (%) 100
Microscopy (Direct examination) Positive 46 0
Negative 2 64
Sensitivity (%) 95.8
Specificity (%) 100
Culture Positive 41 0
Negative 5 66
Sensitivity (%) 89.1
Specificity (%) 100