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Table 2 Bivariate and multivariate logistic regression of risk factors for colistin methanesulfonate-associated nephrotoxicity

From: High dose intravenous colistin methanesulfonate therapy is associated with high rates of nephrotoxicity; a prospective cohort study from Saudi Arabia

  Entire cohort (n = 67) Nephrotoxicity group (n = 51) No nephrotoxicity group (n = 16) Bivariate analysis Multivariate logistic regression
P value OR (95% CI) P value
Age (years)a 57.48 (±24.01) 61.53 (±22.44) 44.56 (±24.99) 0.013 0.98 (0.96–1.04) 0.494
Body weight (kg)a 73.67 (±21.33) 72.78 (±18.90) 76.50 (±28.26) 0.547 - -
Male genderb 45 (67.2%) 33(76.1%) 12 (75.0%) 0.55 - -
Charlson Co-morbidity Scorea 2.88 (±2.39) 2.86 (±2.14) 2.94 (±3.15) 0.914 - -
Diabetes mellitusb 29 (43.2%) 25 (49.0%) 4 (25.0%) 0.15 0.52 (0.06–4.87) 0.568
Baseline CrCl (mL/min)a 133.60 (±92.54) 126.02 (±85.57) 157.94 (±111.52) 0.23 0.99 (0.98–4.87) 0.108
Baseline serum albumin (mg/L)a 28.65 (±4.45) 27.86 (±4.19) 31.19 (±4.48) 0.008 0.72 (0.57–0.93) 0.010
Intensive care unit careb 21 (31.3%) 13 (25.5%) 8 (50.0%) 0.12 16.38 (1.37–195.55) 0.027
Receipt of CMS Loading dose 52 (77.6%) 39 (76.5%) 13 (81.3%) 1.0 - -
CMS Dose (mU/kg/day)a 0.11 (±0.04) 0.11 (±0.04) 0.10 (±0.04) 0.48 - -
Cumulative CMS dose (mU)a 101.21 (±47.37) 106.47 (±45.91 84.44 (±49.56) 0.105 1.00 (1.00–1.00) 0.133
Duration of CMS therapy (days)a 13.76 (±6.77) 14.16 (±5.54) 12.50 (±9.86) 0.397 0.96 (0.83–1.11) 0.555
Number of concomitant nephrotoxic agentsa 0.71 (±0.62) 0.76 (±0.65) 0.56 (±0.51) 0.26 2.37 (0.50–11.19) 0.277
Concomitant vancomycin therapyb 33 (49.3%) 24 (47.1%) 9 (56.3%) 0.576 - -
Concomitant furosemide therapyb 11 (16.4%) 8 (15.7%) 3 (18.75%) 0.715 - -
Concomitant aminoglycoside therapyb 3 (4.47%) 2 (3.92%) 1 (6.25%) 0.559 - -
Concomitant NSAIDb 2 (2.98%) 2 (3.92%) 0 (0.0%) 1.00 - -
Concomitant radiological contrastb 1 (1.49%) 1 (1.96%) 0 (0.0%) 1.00 - -
Concomitant amphotericin b therapyb 0 (0.0%) 0 (0.0%) 0 (0.0%) 1.00 - -
  1. CrCl = creatinine clearance; CMS = colistin methanesulfonate; OR = odds ratio; NSAID = Non-steroidal anti-inflammatory drugs.
  2. aMean (± standard deviation).
  3. bNumber (percentage).