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Table 1 Cumulative inhibition at MIC values by organism grouping and antimicrobial agent

From: Use of linezolid susceptibility test results as a surrogate for the susceptibility of Gram-positive pathogens to tedizolid, a novel oxazolidinone

Organism grouping (no. tested) Cumulative number (%) of isolates inhibited at MIC value (μg/ml)
Antimicrobial agent 0.06 0.12 0.25a 0.5 1 2 4 8 >8
S. aureus (7187)
Tedizolid 17 (0.2) 550 (7.7) 5024(69.9) 7163 (99.6) 7175 (99.8) 7180 (99.9) 7184 (99.9) 7186 (99.9) 7187 (100)
Linezolid -- -- 7 (0.1) 29 (0.4) 1580 (21.9) 6813 (94.7) 7167 (99.7) 7170 (99.7) 7187 (100)
Staphylococcal species (non-S. aureus)b (674)
Tedizolid 30 (4.5) 323 (47.9) 597 (88.5) 664 (98.5) 669 (99.2) 669 (99.2) 673 (99.8) 674 (100) 674 (100)
Linezolid -- -- 6 (0.9) 163 (24.1) 575 (85.3) 660 (97.9) 668 (99.1) 669 (99.2) 674 (100)
Enterococcus spp. (1241)
Tedizolid 8 (0.6) 71 (5.7) 701 (56.4) 1224 (98.6) 1237 (99.6) 1240 (99.9) 1241 (100) 1241 (100) 1241 (100)
Linezolid -- -- 5 (0.4) 39 (3.1) 544 (43.8) 1219 (98.2) 1237 (99.6) 1238 (99.7) 1241 (100)
Streptococcus spp. (1600)
Tedizolid 80 (5.0) 790 (49.3) 1592 (99.5) 1600 (100) 1600 (100) 1600 (100) 1600 (100) 1600 (100) 1600 (100)
Linezolid -- -- 56 (3.5) 474 (29.6) 1516 (94.7) 1599 (99.9) 1600 (100) 1600 (100) 1600 (100)
Streptococcus anginosus groupc (91)
Tedizolid 35 (38.4) 75 (82.4) 91 (100) 91 (100) 91 (100) 91 (100) 91 (100) 91 (100) 91 (100)
Linezolid -- -- 35 (38.4) 67 (73.6) 91 (100) 91 (100) 91 (100) 91 (100) 91 (100)
  1. Abbreviations: MIC minimum inhibitory concentration, MIC 50 MIC required to inhibit growth of 50% of isolates, MIC 90 MIC required to inhibit growth of 90% of isolates.
  2. Italics indicate MIC50.
  3. Bolding indicates MIC90.
  4. aAn MIC value of 0.25 was the lowest MIC value tested for linezolid. Linezolid results should be read as ≤0.25 μg/ml.
  5. bIncludes isolates of S. capitis (28), S. caprae (4), S. cohnii (2), S. epidermidis (405), S. haemolyticus (52), S. hominis (56), S. intermedius (7), S. lugdunensis (47), S. pasteuri (1), S. pettenkoferi (1), S. saprophyticus (28), S. schleiferi (6), S. simulans (14), S. warneri (12), S. xylosus (2), and unspeciated coagulase-negative Staphylococcus spp. (9).
  6. cIncludes isolates of S. anginosus, S. intermedius, and S. constellatus.