Table 1 Cumulative inhibition at MIC values by organism grouping and antimicrobial agent
Organism grouping (no. tested) | Cumulative number (%) of isolates inhibited at MIC value (μg/ml) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Antimicrobial agent | 0.06 | 0.12 | 0.25a | 0.5 | 1 | 2 | 4 | 8 | >8 |
S. aureus (7187) | |||||||||
Tedizolid | 17 (0.2) | 550 (7.7) | 5024(69.9) | 7163 (99.6) | 7175 (99.8) | 7180 (99.9) | 7184 (99.9) | 7186 (99.9) | 7187 (100) |
Linezolid | -- | -- | 7 (0.1) | 29 (0.4) | 1580 (21.9) | 6813 (94.7) | 7167 (99.7) | 7170 (99.7) | 7187 (100) |
Staphylococcal species (non-S. aureus)b (674) | |||||||||
Tedizolid | 30 (4.5) | 323 (47.9) | 597 (88.5) | 664 (98.5) | 669 (99.2) | 669 (99.2) | 673 (99.8) | 674 (100) | 674 (100) |
Linezolid | -- | -- | 6 (0.9) | 163 (24.1) | 575 (85.3) | 660 (97.9) | 668 (99.1) | 669 (99.2) | 674 (100) |
Enterococcus spp. (1241) | |||||||||
Tedizolid | 8 (0.6) | 71 (5.7) | 701 (56.4) | 1224 (98.6) | 1237 (99.6) | 1240 (99.9) | 1241 (100) | 1241 (100) | 1241 (100) |
Linezolid | -- | -- | 5 (0.4) | 39 (3.1) | 544 (43.8) | 1219 (98.2) | 1237 (99.6) | 1238 (99.7) | 1241 (100) |
Streptococcus spp. (1600) | |||||||||
Tedizolid | 80 (5.0) | 790 (49.3) | 1592 (99.5) | 1600 (100) | 1600 (100) | 1600 (100) | 1600 (100) | 1600 (100) | 1600 (100) |
Linezolid | -- | -- | 56 (3.5) | 474 (29.6) | 1516 (94.7) | 1599 (99.9) | 1600 (100) | 1600 (100) | 1600 (100) |
Streptococcus anginosus groupc (91) | |||||||||
Tedizolid | 35 (38.4) | 75 (82.4) | 91 (100) | 91 (100) | 91 (100) | 91 (100) | 91 (100) | 91 (100) | 91 (100) |
Linezolid | -- | -- | 35 (38.4) | 67 (73.6) | 91 (100) | 91 (100) | 91 (100) | 91 (100) | 91 (100) |