Antimicrobial activity of alexidine, chlorhexidine and cetrimide against Streptococcus mutans biofilm

Table 1 Antimicrobial activity against Streptococcus mutans biofilm of chlorhexidine, cetrimide and alexidine solutions

Antimicrobial solution (n = 12/group)	Minimum CFUs/mL	Maximum CFUs/mL	Units with E	Kill percentage mean (standard deviation)*
2% CHX	0	61.000	6/12	96.57 (9.82)^1,3
0.2% CHX	3.000	59.000	0/12	85.18 (10.60)²
2% ALX	0	19	10/12	99.99 (0.0033)¹
1% ALX	0	72	8/12	99.99 (0.014)¹
0.5% ALX	0	3.600	7/12	99.78 (0.58)^1,3
0.2% ALX	0	4.700	5/12	99.56 (0.86)³
0.2% CTR	0	2.800	9/12	99.84 (0.45)^1,3

CHX: chlorhexidine; ALX: alexidine; CTR: cetrimide.
E: eradication or 100% kill percentage with respect to the control.
Control values: Minimum: 60.000, maximum: 380.000, mean (standard deviation): 178.333 (105.298).
*^{1, 2, 3}The same number shows differences that are not statistically significant determined by Student T test previously subjecting data to Anscombe transformation.
p value of comparisons: 2% CHX vs 0.2% CHX: p < 0.001, 2% CHX vs 2% ALX: p = 0.134, 2% CHX vs 1% ALX: p = 0.144, 2% CHX vs 0.5% ALX: p = 0.267, 2% CHX vs 0.2% ALX: p = 0.424, 2% CHX vs 0.2% CTR: p = 0.221, 0.2% CHX vs 2% ALX: p < 0.001, 0.2% CHX vs 1% ALX: p < 0.001, 0.2% CHX vs 0.5% ALX: p < 0.001, 0.2% CHX vs 0.2% ALX: p < 0.001, 0.2% CHX vs 0.2% CTR: p < 0.001, 2% ALX vs 1% ALX: p = 0.174, 2% ALX vs 0.5% ALX: p = 0.127, 2% ALX vs 0.2% ALX: p = 0.04, 2% ALX vs 0.2%CTR: p = 0.212, 1% ALX vs 0.5% ALX: p = 0.156, 1% ALX vs 0.2% ALX: p = 0.04, 1% ALX vs 0.2% CTR: p = 0.275, 0.5% ALX vs 0.2% ALX: p = 0.413, 0.5% ALX vs 0.2% CTR: p = 0.713, 0.2% ALX vs 0.2% CTR: p = 0.247.

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