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Table 4 Comparison of commercially prepared 2-AQ MICs versus frontline drug MICs against multidrug-resistant B. cepacia complex clinical isolates

From: Screening a mushroom extract library for activity against Acinetobacter baumannii and Burkholderia cepacia and the identification of a compound with anti-Burkholderia activity

      Antibacterial drug MIC (μg/ml)
Bacterial strain SXT a NN GM AN ATM PIP TZP TIC CAZ FEP MEM IPM LVX 2-AQ
B. multivorans AU5573 0.25 256 64 64 16 32 8 128 8 8 4 32 1 64
B. multivorans AU7455 1 64 >64 >64 16 8 8 32 8 2 2 32 2 32
B. multivorans AU10398 1 >256 >64 >64 32 -b 32 >128 >64 >32 8 16 16 16
B. cenocepacia AU6550 4 >256 >64 >64 >64 - 128 >128 16 >32 16 >32 16 16
B. cenocepacia AU9292 >4 >256 >64 >64 >64 >128 >128 >128 32 >32 16 >32 >16 64
B. cenocepacia AU10321 4 >256 >64 >64 >64 >64 >128 >128 64 >32 32 >32 >16 32
  1. aSXT = trimethoprim/sulfa, NN = tobramycin, GM = gentamicin, AN = amikacin, ATM = aztreonam, PIP = piperacillin, TZP = piperacillin/tazobactam, TIC = ticaricillin/clavulanic acid,, CAZ = ceftazidime, FEP = cefepime, MEM = meropenem, IPM = imipenem, LVX = levofloxacin, and 2-AQ = 2-aminoquinoline.
  2. b - = not determined.