Skip to main content

Table 1 In vitro activities of fluoroquinolones against S. pneumoniae isolates with mutations in the parC and gyrA genes.

From: Characterization of the quinolone resistant determining regions in clinical isolates of pneumococci collected in Canada

  Minimum Inhibitory Concentration (mg/L)
Number of Isolates
  0.015 0.03 0.06 0.12 0.25 0.5 1 2 4 8 16 32 64 128 Total
parC only                
Ciprofloxacin 0 0 0 0 2 182 408 256 136 39 5 2 2 0 1032
Levofloxacin 0 0 1 0 0 205 580 213 15 3 4 1 0 0 1022
Moxifloxacin 0 5 130 489 343 16 8 2 1 1 0 0 0 0 995
gyrA only                
Ciprofloxacin 0 0 0 0 0 1 9 9 2 5 2 2 0 0 30
Levofloxacin 0 0 0 0 0 1 13 5 3 4 4 0 0 0 30
Moxifloxacin 0 0 1 6 8 4 5 4 2 0 0 0 0 0 30
parC & g yrA                
Ciprofloxacin 0 0 0 0 0 0 3 3 4 29 73 126 55 5 298
Levofloxacin 0 0 0 0 0 1 6 0 13 78 151 37 11 1 298
Moxifloxacin 0 0 0 4 6 3 26 136 87 18 1 1 0 0 282