Characterization of the quinolone resistant determining regions in clinical isolates of pneumococci collected in Canada

Table 1 In vitro activities of fluoroquinolones against S. pneumoniae isolates with mutations in the parC and gyrA genes.

	Minimum Inhibitory Concentration (mg/L) Number of Isolates
	0.015	0.03	0.06	0.12	0.25	0.5	1	2	4	8	16	32	64	128	Total
*parC* only
Ciprofloxacin	0	0	0	0	2	182	408	256	136	39	5	2	2	0	1032
Levofloxacin	0	0	1	0	0	205	580	213	15	3	4	1	0	0	1022
Moxifloxacin	0	5	130	489	343	16	8	2	1	1	0	0	0	0	995
*gyrA* only
Ciprofloxacin	0	0	0	0	0	1	9	9	2	5	2	2	0	0	30
Levofloxacin	0	0	0	0	0	1	13	5	3	4	4	0	0	0	30
Moxifloxacin	0	0	1	6	8	4	5	4	2	0	0	0	0	0	30
*parC* & g *yrA*
Ciprofloxacin	0	0	0	0	0	0	3	3	4	29	73	126	55	5	298
Levofloxacin	0	0	0	0	0	1	6	0	13	78	151	37	11	1	298
Moxifloxacin	0	0	0	4	6	3	26	136	87	18	1	1	0	0	282

ISSN: 1476-0711