Figure 2

Distribution of pneumococcal isolates with amino acid substitutions in parC and gyrA against ciprofloxacin MIC. The figure shows that isolates with amino acid substitutions at positions 79 of parC and 81 of gyrA or at positions 79 of parC and 85 of gyrA have 32-fold higher ciprofloxacin MIC compared to isolates with no mutation in parC and gyrA. Similarly, substitutions at positions 83 of parC and 81 of gyrA result in 16-fold increase in ciprofloxacin MIC.