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Table 9 Identification and location of mutation of rpoB gene (20) in RIF resistant cases, and of KatG gene (24) in INH resistant cases

From: Genotypic detection of rifampicin and isoniazid resistant Mycobacterium tuberculosis strains by DNA sequencing: a randomized trial

Mutated gene Codon

Nucleotide Substitution

Amino acid change

Mutation

Mutated rpoB (20)

  

No

%

Codon 516

GAC --> GTC

Aspartate -->Valine

4

20

Codon 522

TCG --> TTG

Serine -->Leucine

1

5

Codon 526

CAC --> GAC

Histidine -->Aspartate

6

30

Codon 531

TCG --> TTG

Serine -->Leucine

9

45

Mutated KatG (24)

    

Codon 315

AGC --> ACC

Serine -->Threonine

24

100