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Table 2 MIC50 values of intestinal dominant E. coli population in studied groups

From: The occurrence of antimicrobial resistance and class 1 integrons among commensal Escherichia coli isolates from infants and elderly persons

Antibiotics

MIC50 (mg/L) of all isolates

MIC50 of integron-negative/integron-positive isolates

Statistical significance*

 

Children

Elderly

 
 

Group 1

Group 2

Group 3

Group 4

 

Ampicillin

5

31/7

6

101/6

2

22/256

6

62/36

1 p = 0.05

2 p = 0.001

Cefuroxime

2

21/2.52

6

61/82

2

23/24

6

53/64

1 p < 0.001

2 p < 0.001

3 p < 0.001

4 p < 0.001

Cefotaxime

0.064

0.0321/0.094

0.125

0.1251/0.125

0.047

0.0472/0.0473

0.125

0.1252/0.1253

1 p = 0.028

2 p < 0.001

3 p = 0.001

Gentamicin

0.38

0.38/0.441

1.5

1.0/1.51

0.5

0.5/0.38

0.38

0.38/0.38

1 p = 0.011

Ciprofloxacin

0.012

0.012/0.0121

0.023

0.023/0.0231

0.008

0.0082/0.0123

0.016

0.0162/0.0163

1 p = 0.004

2 p < 0.001

3 p = 0.048

Sulfamethoxazole

512

20/512

512

512/512

24

241/512

64

2281/56

1 p = 0.03

  1. *Statistical significance (by the Mann-Whitney test) has been shown separately for integron-positive and negative strains comparing groups with medical intervention to groups without intervention (i.e. antibiotic-naive children versus treated ones; hospitalized elderly versus non-hospitalized). P values for the comparison of the other groups have been shown in the text.