Skip to main content

Table 2 Chequerboard results obtained with tigecycline in combination with seven antibiotics in 24 A. baumannii isolates

From: In vitro activity of tigecycline in combination with various antimicrobials against multidrug resistant Acinetobacter baumannii

 

Effect (FICI value) of TIG in combination with a

Study code

LVX

TZP

AMK

IPM

RIF

SAM

CS

5

Sy (0.31)

In (2.03)

An (4.06)

In (0.75)

In (0.62)

In (1.25)

In (0.62)

11

Sy (0.31)

In (2.03)

Sy (0.50)

In (0.75)

In (0.62)

In (1.50)

In (0.56)

16

Sy (0.50)

In (1.03)

In (0.62)

In (0.75)

In (1.06)

In (1.50)

Sy (0.50)

28

In (0.62)

In (2.03)

An (8.06)

In (0.75)

In (1.00)

In (1.50)

In (0.56)

29

In (0.75)

In (2.06)

In (0.75)

In (0.75)

In (1.00)

In (1.50)

In (1.12)

32

In (1.12)

In (2.06)

In (1.25)

In (0.75)

In (1.00)

In (1.50)

In (0.62)

50

In (0.75)

An (8.03)

In (0.75)

In (0.75)

In (0.75)

In (2.50)

In (0.56)b

62

In (1.00)

In (1.00)

In (1.00)

Sy (0.37)

In (0.62)

In (1.00)

In (0.62)

63

In (0.56)

In (2.03)

In (0.56)

In (0.75)

In (0.75)

In (1.25)

In (0.56)

71

In (0.75)

In (2.03)

Sy (0.50)

In (0.75)

In (0.56)

In (1.25)

In (0.56)

73

In (0.75)

An (4.06)

In (1.12)

In (1.12)

In (1.50)

In (2.50)

An (4.25)

75

Sy (0.31)

In (0.75)

In (0.62)

In (0.62)

In (0.62)

In (0.56)

Sy (0.50)

80

In (0.62)

An (4.06)

In (0.62)

Sy (0.37)

In (1.00)

In (1.25)

In (0.62)

82

In (0.56)

In (0.75)

In (2.12)

In (1.25)

In (0.62)

In (0.75)

In (1.25)

86

In (1.00)

An (4.06)

In (1.00)

In (0.75)

In (1.00)

In (1.50)

In (0.56)

87

In (0.56)

In (0.75)

In (0.56)

In (0.75)

In (2.12)

In (0.75)

In (1.12)

88

In (0.62)

In (1.00)

An (4.03)

In (0.75)

In (0.75)

In (0.62)

In (0.75)

89

In (0.62)

In (1.50)

In (1.06)

In (0.75)

In (0.75)

In (0.75)

In (1.12)

93

In (0.56)

An (4.06)

In (2.06)

In (1.00)

An (4.25)

In (1.00)

In (0.62)

100

In (0.56)

In (2.03)

In (1.00)

In (1.00)

In (1.00)

In (0.75)

In (0.62)

105

In (2.03)

An (4.03)

In (0.75)

In (2.50)

In (2.50)

An (4.25)

In (2.25)

115

In (1.06)

An (4.06)

In (2.25)

In (1.50)

In (1.50)

In (2.25)

In (1.06)

RUH 134

In (1.50)c

An (4.12)

In (0.75)

In (1.50)c

In (1.00)

In (2.12)

In (1.06)

RUH 875

In (1.50)c

In (2.06)

In (2.12)

In (1.00)c

In (1.00)

In (2.06)

In (2.12)

  1. a Synergistic and antagonistic interactions are in bold and italics, respectively.
  2. b The FICI value of the tigecycline/colistin combination has been calculated considering a MIC value of 32 mg/L for colistin [see Additional file 1].
  3. c FICI value of tigecycline in combination with levofloxacin and imipenem has been calculated considering a MIC value of 0.125 mg/L for both levofloxacin and imipenem [see Additional file 1].
Back to article page

Annals of Clinical Microbiology and Antimicrobials

ISSN: 1476-0711

Contact us