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Table 2 Chequerboard results obtained with tigecycline in combination with seven antibiotics in 24 A. baumannii isolates

From: In vitro activity of tigecycline in combination with various antimicrobials against multidrug resistant Acinetobacter baumannii

  Effect (FICI value) of TIG in combination with a
Study code LVX TZP AMK IPM RIF SAM CS
5 Sy (0.31) In (2.03) An (4.06) In (0.75) In (0.62) In (1.25) In (0.62)
11 Sy (0.31) In (2.03) Sy (0.50) In (0.75) In (0.62) In (1.50) In (0.56)
16 Sy (0.50) In (1.03) In (0.62) In (0.75) In (1.06) In (1.50) Sy (0.50)
28 In (0.62) In (2.03) An (8.06) In (0.75) In (1.00) In (1.50) In (0.56)
29 In (0.75) In (2.06) In (0.75) In (0.75) In (1.00) In (1.50) In (1.12)
32 In (1.12) In (2.06) In (1.25) In (0.75) In (1.00) In (1.50) In (0.62)
50 In (0.75) An (8.03) In (0.75) In (0.75) In (0.75) In (2.50) In (0.56)b
62 In (1.00) In (1.00) In (1.00) Sy (0.37) In (0.62) In (1.00) In (0.62)
63 In (0.56) In (2.03) In (0.56) In (0.75) In (0.75) In (1.25) In (0.56)
71 In (0.75) In (2.03) Sy (0.50) In (0.75) In (0.56) In (1.25) In (0.56)
73 In (0.75) An (4.06) In (1.12) In (1.12) In (1.50) In (2.50) An (4.25)
75 Sy (0.31) In (0.75) In (0.62) In (0.62) In (0.62) In (0.56) Sy (0.50)
80 In (0.62) An (4.06) In (0.62) Sy (0.37) In (1.00) In (1.25) In (0.62)
82 In (0.56) In (0.75) In (2.12) In (1.25) In (0.62) In (0.75) In (1.25)
86 In (1.00) An (4.06) In (1.00) In (0.75) In (1.00) In (1.50) In (0.56)
87 In (0.56) In (0.75) In (0.56) In (0.75) In (2.12) In (0.75) In (1.12)
88 In (0.62) In (1.00) An (4.03) In (0.75) In (0.75) In (0.62) In (0.75)
89 In (0.62) In (1.50) In (1.06) In (0.75) In (0.75) In (0.75) In (1.12)
93 In (0.56) An (4.06) In (2.06) In (1.00) An (4.25) In (1.00) In (0.62)
100 In (0.56) In (2.03) In (1.00) In (1.00) In (1.00) In (0.75) In (0.62)
105 In (2.03) An (4.03) In (0.75) In (2.50) In (2.50) An (4.25) In (2.25)
115 In (1.06) An (4.06) In (2.25) In (1.50) In (1.50) In (2.25) In (1.06)
RUH 134 In (1.50)c An (4.12) In (0.75) In (1.50)c In (1.00) In (2.12) In (1.06)
RUH 875 In (1.50)c In (2.06) In (2.12) In (1.00)c In (1.00) In (2.06) In (2.12)
  1. a Synergistic and antagonistic interactions are in bold and italics, respectively.
  2. b The FICI value of the tigecycline/colistin combination has been calculated considering a MIC value of 32 mg/L for colistin [see Additional file 1].
  3. c FICI value of tigecycline in combination with levofloxacin and imipenem has been calculated considering a MIC value of 0.125 mg/L for both levofloxacin and imipenem [see Additional file 1].