Figure 1

Panel A show the changes over time in adjusted serum calcium and serum phosphate, Panel B the changes in 25-hydroxyvitamin D (25OHD) and parathyroid hormone (PTH) and Panel C the changes in alkaline phosphatase. Monthly doses of cholecalciferol are indicated at the top of each panel. Treatment with rifabutin for infection with MAIC started at month 14. Reference ranges are indicated by the shaded boxes: adjusted serum calcium 2.10–2.55 mmol/L; phosphate 0.70–1.50 mmol/L; alkaline phosphatase 40–120 IU/L; parathyroid hormone 1.7–7.3 pmol/L.