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Table 5 In vitro activity of selected antibacterials against erythromycin-resistant Streptococcus pneumoniae isolates positive for mef(A)

From: Trends in antibacterial resistance among Streptococcus pneumoniae isolated in the USA: update from PROTEKT US Years 1–4

  Year 1 (n = 2,157) Year 2 (n = 1,881) Year 3 (n = 2,029) Year 4 (n = 1,543)
Antibacterial MIC90 (μg/mL) Susceptibility (%) MIC90 (μg/mL) Susceptibility (%) MIC90 (μg/mL) Susceptibility (%) MIC90 (μg/mL) Susceptibility (%)
Penicillin 4 12.3 4 13.0 4 14.3 4 19.0
Amoxicillin-clavulanate ≥ 8 71.8 4 78.8 4 82.9 2 90.7
Cefuroxime 8 23.4 8 28.8 8 34.4 8 44.5
Trimethroprim-sulfamethaxazole ≥ 8 12.4 ≥ 8 17.1 ≥ 8 19.0 ≥ 8 27.6
Tetracycline ≥ 8 71.7 ≥ 8 71.4 ≥ 8 76.5 ≥ 8 81.2
Erythromycin 16 0 16 0 16 0 16 0
Azithromycin 32 0 32 0.2 16 0 32 0
Clarithromycin 16 0.1 8 0.4 8 0.1 16 0.1
Levofloxacin 1 99.0 1 97.7 1 98.6 1 98.6
Telithromycin 1 99.1 0.5 99.9 0.5 99.9 0.5 99.9
  1. MIC, minimal inhibitory concentration.