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Table 5 In vitro activity of selected antibacterials against erythromycin-resistant Streptococcus pneumoniae isolates positive for mef(A)

From: Trends in antibacterial resistance among Streptococcus pneumoniae isolated in the USA: update from PROTEKT US Years 1–4

 

Year 1 (n = 2,157)

Year 2 (n = 1,881)

Year 3 (n = 2,029)

Year 4 (n = 1,543)

Antibacterial

MIC90 (μg/mL)

Susceptibility (%)

MIC90 (μg/mL)

Susceptibility (%)

MIC90 (μg/mL)

Susceptibility (%)

MIC90 (μg/mL)

Susceptibility (%)

Penicillin

4

12.3

4

13.0

4

14.3

4

19.0

Amoxicillin-clavulanate

≥ 8

71.8

4

78.8

4

82.9

2

90.7

Cefuroxime

8

23.4

8

28.8

8

34.4

8

44.5

Trimethroprim-sulfamethaxazole

≥ 8

12.4

≥ 8

17.1

≥ 8

19.0

≥ 8

27.6

Tetracycline

≥ 8

71.7

≥ 8

71.4

≥ 8

76.5

≥ 8

81.2

Erythromycin

16

0

16

0

16

0

16

0

Azithromycin

32

0

32

0.2

16

0

32

0

Clarithromycin

16

0.1

8

0.4

8

0.1

16

0.1

Levofloxacin

1

99.0

1

97.7

1

98.6

1

98.6

Telithromycin

1

99.1

0.5

99.9

0.5

99.9

0.5

99.9

  1. MIC, minimal inhibitory concentration.