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Table 1 Interaction of MUC7 12-mer in the combination with salts or EDTA against C. albicans

From: Factors affecting antimicrobial activity of MUC7 12-mer, a human salivary mucin-derived peptide

 

MIC (μM)a

  

Combination pairs

alone

combined

FICb

FICic

MUC7 12-mer

50

25

0.5

 

Na+

>250

31

0.062

0.562 (ADD)d

MUC7 12-mer

50

100

2

 

K+

>250

250

0.5

2.5 (IND)

MUC7 12-mer

12.50

50.00

4.00

 

Ca2+

>160

80.00

0.50

4.50 (ANT)

MUC7 12-mer

12.50

25.00

1.00

 

Mg2+

>160

80.00

0.25

1.25 (IND)

MUC7 12-mer

6.25

3.13

0.50

 

Zn2+

160.00

7.50

0.05

0.55 (ADD)

MUC7 12-mer

18.75

2.35

0.13

 

EDTA

75.00

6.25

0.09

0.22 (SYN)

  1. a Minimal inhibitory concentrations (MIC) was determined at the endpoint of MIC-0, which is defined as the lowest agent concentration showing no more than 10% growth in comparison to that of the growth control. The data represents the median obtained from three independent experiments.
  2. b FIC is a fraction inhibitory concentration that was calculated by dividing the MIC value of agent in combination by the MIC value of the agent alone.
  3. c FICi is a FIC index, indicating the sum of the FICs of the two agents in the pairs.
  4. d Interactions: SYN, synergism (FICi <0.5); ADD, additivity (FICi 0.5–1.0); IND, indifference (FICi 1.0 – 4.0); ANT, antagonism (FICi >4).