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Table 1 Interaction of MUC7 12-mer in the combination with salts or EDTA against C. albicans

From: Factors affecting antimicrobial activity of MUC7 12-mer, a human salivary mucin-derived peptide

  MIC (μM)a   
Combination pairs alone combined FICb FICic
MUC7 12-mer 50 25 0.5  
Na+ >250 31 0.062 0.562 (ADD)d
MUC7 12-mer 50 100 2  
K+ >250 250 0.5 2.5 (IND)
MUC7 12-mer 12.50 50.00 4.00  
Ca2+ >160 80.00 0.50 4.50 (ANT)
MUC7 12-mer 12.50 25.00 1.00  
Mg2+ >160 80.00 0.25 1.25 (IND)
MUC7 12-mer 6.25 3.13 0.50  
Zn2+ 160.00 7.50 0.05 0.55 (ADD)
MUC7 12-mer 18.75 2.35 0.13  
EDTA 75.00 6.25 0.09 0.22 (SYN)
  1. a Minimal inhibitory concentrations (MIC) was determined at the endpoint of MIC-0, which is defined as the lowest agent concentration showing no more than 10% growth in comparison to that of the growth control. The data represents the median obtained from three independent experiments.
  2. b FIC is a fraction inhibitory concentration that was calculated by dividing the MIC value of agent in combination by the MIC value of the agent alone.
  3. c FICi is a FIC index, indicating the sum of the FICs of the two agents in the pairs.
  4. d Interactions: SYN, synergism (FICi <0.5); ADD, additivity (FICi 0.5–1.0); IND, indifference (FICi 1.0 – 4.0); ANT, antagonism (FICi >4).