Patient | MRSA strains | VCM MIC (mg/L)a | AUCb (days) | DTAc (days) | DTCRPd (days) | DTWBCe (days) | DBCPf (days) | Survival at one month | VTRg |
|---|
1 | 98-7 | 2 | 18.94 | 10 | 10 | <10,000 | n.a. | dead | Poor |
2 | 99-7 | 2 | 12.3 | 10 | 10 | > 10,000 | 10 | dead | Poor |
3 | 01-3 | 1 | 10.95 | 6 | 8 | <10,000 | n.a. | alive | Good |
4 | 02-6 | 2 | 22.01 | 19 | 19 | > 10,000 | n.a. | dead | Poor |
5 | 03-1 | 1 | 9.12 | 5 | 6 | 1 | 8 | dead | Good |
6 | 03-3 | 1 | 10.57 | 4 | 8 | 9 | 15 | alive | Good |
7 | 03-5 | 1 | 8.54 | 3 | 6 | <10,000 | n.a. | alive | Good |
8 | 03-9 | 1 | 12.56 | 12 | 2 | <10,000 | 2 | dead | Good |
9 | 03-10 | 2 | 23.11 | 25 | 12 | 7 | 13 | dead | Poor |
10 | 03-13 | 1 | 7.62 | 2 | 4 | > 10,000 | n.a. | dead | Good |
11 | 03-16 | 1 | 11.56 | 15 | 12 | 8 | n.a. | transferred | Poor |
12 | 03-29 | 1 | 11.14 | 4 | 3 | <10,000 | 4 | alive | Good |
13 | 04-6 | 1 | 10.88 | 5 | 9 | 6 | 16 | dead | Good |
14 | 04-13 | 1 | 9.84 | 4 | 7 | <10,000 | 18 | dead | Good |
15 | 04-15 | 1 | 11.92 | 12 | 12 | < 10,000 | 4 | alive | Poor |
16 | 04-17 | 1 | 12.81 | 14 | 15 | <10,000 | 10 | alive | Poor |
17 | 05-1 | 1 | 11.39 | 10 | 8 | <10,000 | n.a. | discharged | Good |
18 | 05-4 | 1 | 12.19 | 8 | 8 | <10,000 | 11 | alive | Good |
19 | 05-10 | 1 | 13.08 | 6 | 9 | no change | n.a. | alive | Good |
20 | 05-12 | 1 | 12.59 | 10 | 6 | 6 | 9 | dead | Good |
- a) Minimum inhibitory concentrations (MIC) for vancomycin was determined using the agar dilution method in accordance with the Clinical and Laboratory Standards Institute (CLSI) recommendations (9).
- b) AUC (area under curve), measurements of polulation analysis profiles for vancomycin. Log of viable colonies were ploted against vancomycin concentration. AUC represents area covered by curve and graph axis.
- c) DTA (days till afebrile), represents number of days required for the patient's defervesence (body temperature less than 37°C) after commencement of vancomycin therapy.
- d) DTCRP (days till CRP ≦ 30% of maximum), refers to the number of days required for the reduction of patient's CRP level to less than 30% of the maximum value during active infection, after vancomycin was administered.
- e) DTWBC (days till white blood cell < 10,000), refers to the number of days needed for patients' white blood cell level to return to the normal range of ~10,000 cell/mm3.
- f) DBCP refers to duration of MRSA blood culture positivity during vancomycin therapy.
- g) VTR (vancomycin treatment response), was defined as either 'good' or 'poor'. 'Good' repersents complete cure or elimination of clinical symptoms and elimination of laboratory evidence of infection, while 'poor' stands for persistence or worsening of symptoms or death due to MRSA bloodstream infection.
