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Table 2 Comparative activity of the compounds against bacterial and eukaryotic cells

From: Tabebuia avellanedae naphthoquinones: activity against methicillin-resistant staphylococcal strains, cytotoxic activity and in vivo dermal irritability analysis

Compound Minimal Inhibitory Concentrationa (μg/mL) Minimal Toxic Concentrationb (μg/mL)
I 256 >16
II 64 16
III 8 2
IV 8 2
  1. Compounds: I) Lapachol; II) α-lapachone; III) β-lapachone; IV) (±) 3-hydroxy-β-N-lapachone
  2. a MIC – assayed with MRSA strain (ATCC 33591); b assayed on BSC-40 cells