Skip to main content

Table 1 Example drugs affected by rifampicin through different mechanisms

From: Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor

Mediated proteins

 

p-glycoprotein

CYP1A2

CYP2B6

CYP2C9

CYP2C19

CYP3A4

Affected drugs

Anesthetics:

 

Ropivacaine [118]

  

Cyclophosphamine [74]

Alfentanyl [13]

Ropivacaine [118]

 

Analgesics:

 

Mexiletine [119]

   

Codeine [19]

Dapsone [19]

 

Anti-arrhythmics:

     

Mexiletine [119]

Propafenone [120]

Quinidine [19]

 

Anti-cancer drugs:

 

Cyclophosphamide [74]

Ifosfamide [74]

Cyclophosphamide [74]

Ifosfamide [74]

Cyclophosphamide [74]

 

Cyclophosphamide [74]

Imatinib [121]

Tamoxifen [19]

 

Anti-epileptics:

   

Mephenytoin [122]

  
 

Anti-histamines:

Fexofenadine [123]

Terfenadine [123]

    

Fexofenadine [123]

Terfenidine [123]

 

Anti-microbials:

Erythromycin [124]

    

Clarithromtcin [13]

Erythromycin [124]

Itraconazole [13]

Ketoconazole [13]

Miconazole [13]

 

Benzodiazepines:

     

Alprazolam [13]

Diazepam [13]

Midazolam [13]

Triazolam [13]

 

Cardiac drugs:

Digoxin* [88]

Quinidine [13]

Propranolol [13]

Verapamil [19]

Bupropion* [114]

Methadone [19]

Propranolol [13]

Warfarin* [113]

Propranolol [12]

Nifedipine [13]

Propranolol [13]

Verapamil [19]

 

CNS drugs:

 

Amitriptyline [125]

Bupropion [114]

Clomipramine [125]

Clozapine [19]

 

Amitriptyline [125]

Clomipramine [125]

Amitriptyline [119]

Clomipramine [119]

Phenytoin [120]

Clozapine [19]

Amitriptyline [125]

Buspirone [19]

Clomipramine [125]

Zolpidem [19]

 

Gastro-enterology drugs:

 

Ondansetron [19]

    
 

HIV Antivirals:

Indinavir [13]

Nelfinavir [13]

Ritonavir [13]

 

Efavirenz [13]

Nelfinavir [13]

Nelfinavir [12]

Amprenavir [13]

Delavirdine [13]

Indinavir [13]

Nelfinavir [13]

Nevirapine [13]

Ritonavir [13]

Saquinavir [13]

 

HMG CoA Reductase Inhibitors:

   

Fluvastatin [109]

Losartan [109]

Cerivastatin [103]

Atorvastatin [109]

Cerivastatin [109]

Lovastatin [109]

Simvastatin * [108]

 

Hypoglycemics

  

Pioglitazone [127]

Glibenclamide [13]

Glipizide [13]

Nateglinide [13]

Rosiglitazone* [110]

Tolbutamine [13]

Repaglinide [12]

Pioglitazone [127]

 

Immune Modulators:

Cyclosporine [105]

Tacrolimus [17]

Methotrexate [19]

    

Cyclosporine* [105]

Sirolimus [17]

Tacrolimus [19]

 

Steroids:

Cortisol [19]

Corticosterone [19]

Dexamethason [19]

Estradiol [19]

   

Estradiol [19]

Ethinyloestradiol [19]

Hydrocortisone [19]