Mediated proteins | Â | p-glycoprotein | CYP1A2 | CYP2B6 | CYP2C9 | CYP2C19 | CYP3A4 |
---|---|---|---|---|---|---|---|
Affected drugs | Anesthetics: | Â | Ropivacaine [118] | Â | Â | Cyclophosphamine [74] | Alfentanyl [13] Ropivacaine [118] |
 | Analgesics: |  | Mexiletine [119] |  |  |  | Codeine [19] Dapsone [19] |
 | Anti-arrhythmics: |  |  |  |  |  | Mexiletine [119] Propafenone [120] Quinidine [19] |
 | Anti-cancer drugs: |  | Cyclophosphamide [74] Ifosfamide [74] | Cyclophosphamide [74] Ifosfamide [74] | Cyclophosphamide [74] |  | Cyclophosphamide [74] Imatinib [121] Tamoxifen [19] |
 | Anti-epileptics: |  |  |  | Mephenytoin [122] |  |  |
 | Anti-histamines: | Fexofenadine [123] Terfenadine [123] |  |  |  |  | Fexofenadine [123] Terfenidine [123] |
 | Anti-microbials: | Erythromycin [124] |  |  |  |  | Clarithromtcin [13] Erythromycin [124] Itraconazole [13] Ketoconazole [13] Miconazole [13] |
 | Benzodiazepines: |  |  |  |  |  | Alprazolam [13] Diazepam [13] Midazolam [13] Triazolam [13] |
 | Cardiac drugs: | Digoxin* [88] Quinidine [13] | Propranolol [13] Verapamil [19] | Bupropion* [114] Methadone [19] | Propranolol [13] Warfarin* [113] | Propranolol [12] | Nifedipine [13] Propranolol [13] Verapamil [19] |
 | CNS drugs: |  | Amitriptyline [125] Bupropion [114] Clomipramine [125] Clozapine [19] |  | Amitriptyline [125] Clomipramine [125] | Amitriptyline [119] Clomipramine [119] Phenytoin [120] Clozapine [19] | Amitriptyline [125] Buspirone [19] Clomipramine [125] Zolpidem [19] |
 | Gastro-enterology drugs: |  | Ondansetron [19] |  |  |  |  |
 | HIV Antivirals: | Indinavir [13] Nelfinavir [13] Ritonavir [13] |  | Efavirenz [13] | Nelfinavir [13] | Nelfinavir [12] | Amprenavir [13] Delavirdine [13] Indinavir [13] Nelfinavir [13] Nevirapine [13] Ritonavir [13] Saquinavir [13] |
 | HMG CoA Reductase Inhibitors: |  |  |  | Fluvastatin [109] Losartan [109] | Cerivastatin [103] | Atorvastatin [109] Cerivastatin [109] Lovastatin [109] Simvastatin * [108] |
 | Hypoglycemics |  |  | Pioglitazone [127] | Glibenclamide [13] Glipizide [13] Nateglinide [13] Rosiglitazone* [110] Tolbutamine [13] | Repaglinide [12] | Pioglitazone [127] |
 | Immune Modulators: | Cyclosporine [105] Tacrolimus [17] Methotrexate [19] |  |  |  |  | Cyclosporine* [105] Sirolimus [17] Tacrolimus [19] |
 | Steroids: | Cortisol [19] Corticosterone [19] Dexamethason [19] | Estradiol [19] |  |  |  | Estradiol [19] Ethinyloestradiol [19] Hydrocortisone [19] |