Figure 2From: Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptorTranscriptional activation of rifampicin target genes. Pregnane X receptor (PXR) binds with rifampicin in the cytoplasm and enters into nucleus to form a heterodimer with retinoic acid receptor (RXR). The heterodimer binds to the promoter of a target gene to activate the transcription of its open reading frame (ORF).Back to article page