Table 2 Voriconazole plasma concentrations (body weight 18.6 kg)*
From: Severe osteomyelitis caused by Myceliophthora thermophila after a pitchfork injury
Voriconazole Therapy Day | Dose (mg) given every 12 hr | Dose (mg/kg) | Doses prior to kinetics | Peak (mcg/ml) | Trough (mcg/ml) |
|---|---|---|---|---|---|
6 | 75 IV | 4 | 10 | 0.94a | < 0.2 |
14 | 108 IV | 5.8 | 8 | 0.6 | < 0.2 |
24 | 175 IV | 9.4 | 6 | 3.04 | < 0.2 |
34 | 250 PO | 13.4 | 8 | 2.8b | 0.3 |
43 | 250 PO | 13.4 | 26 | 5.35c | 0.3 |
57 | 250 PO | 13.4 | 54 | 2.12b | 0.2 |