Table 1 Distribution of rpoB spontaneous mutations identified after in vitro exposure to rifampicin (8 μg/ml) or rifabutin (0.8 μg/ml).
Number of mutants (%) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Selective agent (Strain) | CAA> CTA Q513L | TCG> TTG S522L | CAC> GAC H526D | CAC> TAC H526Y | CAC> CGC H526R | CAC> CCC H526P | TCG> TTG S531L | TCG> TGG S531W | Others | No. tested |
Rifabutin 0.8 μg/ml | 1 | 0 | 5 | 27 | 6 | 0 | 6 | 1 | 1* | |
(Mtb72) | (2) | (0) | (11) | (60) | (13) | (0) | (13) | (2) | (2) | 47 |
Rifampicin 8 μg/ml | 0 | 1 | 6 | 26 | 4 | 1 | 20 | 0 | 0 | |
(Mtb72) | (0) | (2) | (11) | (45) | (7) | (2) | (35) | (0) | (0) | 58 |