Table 3 In vitro activity of antibacterial agents against 3043 bacterial pathogens isolated from patients with AECB and % susceptibilities to antibacterial agents.

range

50

90

total

MSSA

MRSA

S. pneumoniae N = 1075

Telithromycin

0.004–2

0.015

0.12

99.9

Azithromycin

0.03->64

0.12

>64

71.2

Clarithromycin

0.015->32

0.03

>32

71

Erythromycin

0.03->64

0.06

>64

71

Penicillin

0.008–8

0.03

2

75.3

Amox/clavulanate¹

0.015–8

0.03

2

96.1

Cefuroxime

0.015–16

0.03

2

82.2

Trimethoprim-sulphamethoxazole

0.12–32

0.25

8

62

Tetracycline

0.12–32

0.25

32

69.6

Levofloxacin

0.5->32

1

1

98.9

H. influenzae N = 1037

Telithromycin

0.002–16

1

2

99.6

Azithromycin

0.06–32

1

2

99.7

Clarithromycin

0.25->64

8

16

82.4

Erythromycin

0.25->64

4

8

-²

Ampicillin

0.12–32

0.25

16

87.3

Amox/clavulanate¹

0.12–4

0.5

1

100

Cefuroxime

0.12–16

1

2

99.5

Trimethoprim-sulphamethoxazole

0.03–32

0.06

4

80.7

Tetracycline

0.12–32

0.5

1

97.4

Levofloxacin

0.008–8

0.015

0.015

99.8

M. catarrhalis N = 536

Telithromycin

0.004–0.5

0.06

0.12

Azithromycin

0.06–0.25

0.06

0.06

Clarithromycin

0.25–0.5

0.25

0.25

Erythromycin

0.25–1

0.25

0.25

Ampicillin

0.12–32

8

16

Amox/clavulanate¹

0.12–0.5

0.12

0.25

Cefuroxime

0.12–16

1

2

Trimethoprim-sulphamethoxazole

0.06–4

0.25

0.5

Tetracycline

0.12–32

0.25

0.5

Levofloxacin

0.008–0.06

0.03

0.03

S. aureus N = 335

Telithromycin

0.03->32

0.06

>32

85.1

98.9

24.2

Azithromycin

0.12->64

1

>64

70.4

84.2

9.7

Clarithromycin

0.03->32

0.25

>32

70.4

84.2

9.7

Erythromycin

0.12->64

0.25

>64

70.4

84.6

9.7

Penicillin

0.008–8

4

8

23.6

28.9

0

Amox/clavulanate¹

0.06–8

0.5

8

83.1

100

0

Cefuroxime

0.12–16

1

16

81.2

100

0

Trimethoprim-sulphamethoxazole

0.12–32

0.12

0.25

94.9

97.4

83.9

Tetracycline

0.12–32

0.5

32

84.8

92.7

50

Levofloxacin

0.5–64

0.5

8

76.7

81.7

6.5

H. parainfluenzae N = 60

Telithromycin

0.06–4

1

2

100

Azithromycin

0.06–2

0.5

1

100

Clarithromycin

0.25–16

4

8

93.3

Erythromycin

0.5–8

2

4

-²

Ampicillin

0.12–32

0.25

1

90

Amox/clavulanate¹

0.12–2

0.5

1

100

Cefuroxime

0.12–4

0.25

0.5

100

Trimethoprim-sulphamethoxazole

0.03–32

0.03

1

88.3

Tetracycline

0.12–16

0.5

4

88.3

Levofloxacin

0.008–8

0.015

0.06

98.4