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Table 3 CD4-cell increase [cells/μl] at week 4, 12, 24 and 48 after initiation of antiretroviral therapy with respect to the MDR1 2677 and 3435 genotypes. Statistical analysis was done with the Kruskall-Wallis test.

From: No influence of the P-glycoprotein polymorphisms MDR1 G2677T/A and C3435T on the virological and immunological response in treatment naïve HIV-positive patients

  

week 4

week 12

week 24

week 48

MDR1

n =

median [cells/μl]

mean [cells/μl]

SA

p =

n =

median [cells/μl]

mean [cells/μl]

SA

p =

n =

median [cells/μl]

mean [cells/μl]

SA

p =

n =

median [cells/μl]

mean [cells/μl]

SA

p =

2677

GG

24

56,5

69,8

81,5

>0.3

22

97,0

130,6

132,4

>0.5

21

107,0

136,1

120,5

>0.8

15

244,0

235,7

132,1

>0.1

 

GT

23

24,0

37,8

82,5

 

20

84,5

144,3

157,2

 

17

132,0

180,8

178,0

 

16

161,5

238,3

218,6

 
 

TT

18

9,5

67,4

117,7

 

16

70,0

143,9

222,3

 

16

95,0

154,5

162,0

 

14

107,5

143,9

159,1

 
 

AG

4

70,5

85,8

68,5

§

4

82,5

74,8

34,4

§

4

54,5

80,3

81,3

§

4

131,5

126,5

71,0

§

 

AT

3

112,0

105,7

13,4

§

3

176,0

180,7

63,8

§

2

154,5

154,5

54,5

§

3

172,0

248,0

118,2

§

3435

CC

20

76,0

84,8

78,6

>0.1

19

91,0

123,0

113,0

>0.9

18

106,5

132,4

112,4

>0.5

13

191,0

220,1

121,5

>0.6

 

CT

34

25,5

47,2

76,1

 

30

85,0

123,7

135,3

 

28

131,0

134,2

106,8

 

25

159,0

187,7

118,4

 
 

TT

18

12,0

61,6

119,1

 

17

74,0

175,9

228,1

 

16

134,0

212,2

214,7

 

15

122,0

223,9

259,3

 

2677/3435

H1

17

72,0

83,1

78,7

>0.1

16

115,0

132,1

119,8

>0.8

15

107,0

142,2

113,3

>0.9

10

194,0

239,6

128,4

>0.5

 

H2

41

20,0

50,8

100,6

 

36

74,5

144,1

188,9

 

33

130,0

168,1

170,9

 

30

134,5

194,2

198,8

 
 

H3

7

19,0

37,3

79,1

§

6

92,0

126,7

161,2

§

6

122,0

120,8

135,7

§

5

302,0

227,8

138,9

§

 

H5

7

87,0

94,3

53,5

§

7

105,0

120,1

71,9

§

7

100,0

131,0

98,7

§

7

172,0

178,6

111,7

§

total

 

72

    

65

    

61

    

52

    
  1. composite genotypes: see methods; §excluded from statistical analysis