Table 2 VL-decrease [log copies/ml] at week 4, 12, 24 and 48 after initiation of antiretroviral therapy with respect to the MDR1 2677 and 3435 genotypes. Statistical analysis was done with the Kruskall-Wallis test.
week 4 | week 12 | week 24 | week 48 | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MDR1 | n = | median [log/ml] | mean [log/ml] | SA | p = | n = | median [log/ml] | mean [log/ml] | SA | p = | n = | median [log/ml] | mean [log/ml] | SA | p = | n = | median [log/ml] | mean [log/ml] | SA | p = | |
2677 | GG | 22 | -2,301 | -2,210 | 0,590 | >0.3 | 22 | -3,048 | -3,287 | 0,682 | >0.05 | 20 | -3,943 | -3,876 | 0,748 | >0.9 | 15 | -3,716 | -3,835 | 0,777 | >0.5 |
GT | 21 | -2,602 | -2,537 | 0,566 | 19 | -3,786 | -3,794 | 0,635 | 17 | -3,929 | -3,933 | 0,499 | 16 | -3,942 | -3,946 | 0,488 | |||||
TT | 17 | -2,495 | -2,372 | 0,651 | 16 | -3,739 | -3,602 | 0,595 | 17 | -4,000 | -3,850 | 0,708 | 14 | -3,977 | -3,795 | 0,615 | |||||
AG | 3 | -2,301 | -2,689 | 0,606 | § | 4 | -3,952 | -4,167 | 0,884 | § | 4 | -4,500 | -4,537 | 0,702 | § | 4 | -4,151 | -4,362 | 0,726 | § | |
AT | 3 | -1,875 | -2,032 | 0,493 | § | 3 | -4,176 | -3,752 | 0,690 | § | 3 | -4,176 | -4,085 | 0,223 | § | 3 | -4,176 | -4,085 | 0,223 | § | |
3435 | CC | 17 | -2,301 | -2,382 | 0,501 | >0.6 | 19 | -3,301 | -3,416 | 0,699 | >0.4 | 17 | -4,000 | -3,974 | 0,685 | >0.7 | 13 | -3,716 | -3,818 | 0,709 | >0.6 |
CT | 32 | -2,247 | -2,363 | 0,640 | 29 | -3,778 | -3,742 | 0,737 | 28 | -3,812 | -3,830 | 0,704 | 25 | -3,929 | -3,984 | 0,614 | |||||
TT | 17 | -2,398 | -2,348 | 0,668 | 17 | -3,602 | -3,530 | 0,595 | 17 | -4,176 | -4,054 | 0,571 | 15 | -4,114 | -3,849 | 0,609 | |||||
2677/3435† | H1 | 15 | -2,398 | -2,398 | 0,531 | >0.8 | 16 | -3,199 | -3,361 | 0,724 | >0.08 | 14 | -3,943 | -3,926 | 0,715 | >0.8 | 10 | -3,659 | -3,774 | 0,787 | >0.4 |
H2 | 38 | -2,548 | -2,463 | 0,611 | 35 | -3,778 | -3,706 | 0,624 | 34 | -3,954 | -3,891 | 0,614 | 30 | -3,954 | -3,875 | 0,556 | |||||
H3 | 7 | -1,778 | -1,806 | 0,502 | § | 6 | -2,827 | -3,089 | 0,506 | § | 6 | -3,827 | -3,761 | 0,807 | § | 5 | -4,176 | -3,958 | 0,741 | § | |
H5 | 6 | -2,261 | -2,361 | 0,642 | § | 7 | -4,176 | -3,989 | 0,833 | § | 7 | -4,301 | -4,343 | 0,594 | § | 7 | -4,176 | -4,243 | 0,584 | § | |
total | 66 | 64 | 61 | 52 | |||||||||||||||||