In vitro activity of vancomycin, quinupristin/dalfopristin, and linezolid against intact and disrupted biofilms of staphylococci

Table 1 Susceptibility of the tested isolates to vancomycin, quinupristin/dalfopristin and linezolid in suspension.

Microorganism ^a	Antimicrobial agents (μg/ml)
	Vancomycin	Quinupristin/dalfopristin	Linezolid
Methicillin-susceptible S. aureus (MSSA)
MIC Range	0.50–1	0.125–0.25	1–2
MIC₉₀	1	0.25	2
MBC Range	8–16	8	>64
MBC₉₀	8	8	>64
Methicillin-resistant S. aureus (MRSA)
MIC Range	0.5–1	0.25–50	1–2
MIC₉₀	1	0.50	2
MBC Range	2–16	4–16	>64
MBC₉₀	8	16	>64
S. epidermidis
MIC Range	2–4	0.06–2	0.50–1
MIC₉₀	2	0.50	1
MBC Range	2–16	0.25–16	>64
MBC₉₀	8	8	>64

^a The MIC defined as the minimum concentration of antibiotic at which growth was completely inhibited while the MBC defined as the minimum concentration at which 99.9% of bacteria was killed.

ISSN: 1476-0711