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Table 3 Summary of clinical trials on eradication of MRSA including the colonization status before treatment, the main outcome and type of bias.

From: Eradication of methicillin-resistant Staphylococcus aureus with an antiseptic soap and nasal mupirocin among colonized patients – an open uncontrolled clinical trial

Preparation for skin antisepsis Number of patients and colonization status (n) Duration of treatment cycle Overall rate of MRSA eradication Type(s) of bias Reference
Octenisept Patients: 5
Skin colonized: 5
Nose colonized: 5
25 days (mean) 20% None [23]
Octenisept Patients: 28
Skin colonized: 10
Nose colonized: 18
5 days (mean) 75% • Early first swab (< 48 h)
• Follow-up < 7 days (n = 9)
• Selection bias (18 patients without dermal colonization)
[25]
Chlorhexidine soap Patients: 98
Skin colonized: 37
Nose colonized: 57
5 days (mean) 25% (with mupirocin) 18% without mupirocin None [8]
Chlorhexidine soap Patients: 12
Skin colonized: 10
Nose colonized: 8
5 – 7 days (range) 83% Treatment bias (all 12 patients received various antibiotics at the same time) [22]
Triclosan soap and foam Patients: 58
Skin colonized: unknown
Nose colonized: unknown
4.2 days (mean) 100% • Selection bias (no evidence of initial dermal colonization)
• Treatment bias (concomitant antibiotic treatment to an unknown number of patients)
• Outcome bias (cultures were mainly obtained during antiseptic treatment)
[24]
Betadine Patients: 35
Skin colonized: unknown
Nose colonized: unknown
5 days (mean) 69% Treatment bias (all patients received also vancomycin 250 mg every 6 h) [18]
Trimethoprim-sulphamethoxazole (160 mg/800 mg twice daily) and rifampin (600 mg once daily) (25) Patients: 25
Skin colonized: unknown
Nose colonized: unknown
2 – 9 days (range) 56% Treatment bias: No antiseptic treatment for the skin was included [10]