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Table 1 Comparison between 1C50 value of clinical isolates (E. histolytica and E. dispar) vs reference strain (HM1: IMSS)

From: In vitro activity of antiamoebic drugs against clinical isolates of Entamoeba histolytica and Entamoeba dispar

COMPOUND

MEAN IC50 OF CLINICAL ISOLATES (μm ± SD)

IC50 VALUE OF REFERENCE STRAIN (μm ± SD)

 

E. histolytica

E. dispar

 

Metronidazole

6.5 ± 0.81***a

15.6 ± 2.12***c

9.5 ± 1.53***b

Chloroquine

18.9 ± 1.39***a

28.9 ± 2.45***c

21.5 ± 1.26***b

Emetine

26.8 ± 1.27***a

32.8 ± 1.68***c

28.0 ± 2.62***b

Tinidazole

8.2 ± 1.09***a

13.2 ± 1.43***c

10.2 ± 0.43***b

  1. Results expressed as mean ± SD from two experiments conducted in duplicate
  2. Student's t-test [*** P < 0.001]
  3. a = Eh Vs Ed Eh – E. histolytica
  4. b = Eh Vs C Ed – E. dispar
  5. c = Ed Vs C C – Reference strain (HM1: IMSS)
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Annals of Clinical Microbiology and Antimicrobials

ISSN: 1476-0711

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