Table 2 In vitro activity of antibacterial agents and percent susceptible against 1336 bacterial pathogens isolated from patients with clinically diagnosed acute sinusitis

Range

50

90

S. pneumoniae

640, 272, 368

Penicillin

0.008 – 8

0.06

2

58.0, 64.7, 53.0

Amoxicillin-clavulanate

0.015 – 8

0.03

2

95.5, 95.2, 95.7

Cefuroxime

0.015 – 16

0.12

8

66.1, 73.2, 60.9

Cefpodoxime

0.12 – 32

0.12

2

65.0, 71.7, 60.1

Trimethoprim-sulphamethoxazole

0.12 – 32

0.5

8

56.3, 58.1, 54.9

Erythromycin

0.03 - >64

0.06

>64

55.9, 60.7, 52.5

Clarithromycin

0.015 - >32

0.06

>32

55.8, 60.7, 52.2

Azithromycin

0.03 - >64

0.12

>64

55.8, 60.7, 52.2

Telithromycin

0.008 – 8

0.015

0.12

99.5, 98.9, 100

H. influenzae

329, 148, 181

Ampicillin

0.12 – 32

0.25

8

88.2, 91.2, 85.6

Amoxicillin-clavulanate

0.12 – 4

0.5

1

100, 100,100

Cefuroxime

0.12 – 16

1

2

99.4, 99.3, 99.5

Cefpodoxime

0.015 – 4

0.06

0.25

99.4, 100, 98.9

Cefdinir

0.06 – 4

0.25

0.5

97.3, 96.0, 98.3

Trimethoprim-sulphamethoxazole

0.03 – 16

0.06

4

84.5, 82.4, 86.2

Erythromycin

0.25 – 16

4

8

-³

Clarithromycin

0.25 – 32

8

16

87.5, 87.2, 87.9

Azithromycin

0.06 – 4

1

2

100, 100,100

Telithromycin

0.06 – 4

1

2

100, 100,100

M. catarrhalis

212, 67, 145

Ampicillin

0.12 – 32

4

16

-

Amoxicillin-clavulanate

0.12 – 0.5

0.12

0.25

-

Cefuroxime

0.12 – 16

1

4

-

Cefpodoxime

0.06 – 4

0.5

1

-

Cefdinir

0.06 – 1

0.12

0.25

-

Trimethoprim-sulphamethoxazole

0.03 – 2

0.12

0.25

-

Erythromycin

0.25 – 1

0.25

0.25

-

Clarithromycin

0.25 – 0.5

0.25

0.25

-

Azithromycin

0.06 – 0.25

0.06

0.06

-

Telithromycin

0.004 – 0.5

0.06

0.12

-

S. aureus

116, 64, 52

Methicillin

-

-

-

90.5, 92.2, 88.5

Amoxicillin-clavulanate

0.06 – 8

0.5

4

90.5, 92.2, 88.5

Cefuroxime

0.5 – 16

1

2

90.5, 92.2, 88.5

Cefpodoxime

1 – 32

2

4

88.8, 92.2, 84.6

Trimethoprim-sulphamethoxazole

0.12 – 32

0.12

0.12

96.6, 95.3, 98.1

Erythromycin

0.03 - >64

0.25

>64

69.0, 73.4, 63.5

Clarithromycin

0.015 - >32

0.25

>32

69.8, 75.0, 63.5

Azithromycin

0.03 - >64

0.5

>64

69.0, 75.0, 61.5

Telithromycin

0.015 - >32

0.06

2

89.7, 89.1, 90.4

S. pyogenes

39, 21, 18

Penicillin

0.008 – 0.008

0.008

0.008

100, 100,100

Amoxicillin-clavulanate

0.008 – 0.03

0.015

0.015

100, 100,100

Cefuroxime

0.015 – 0.015

0.015

0.015

100, 100,100

Cefpodoxime

0.12 – 0.12

0.12

0.12

100, 100,100

Trimethoprim-sulphamethoxazole

0.12 – 0.5

0.12

0.25

-

Erythromycin

0.03 – 4

0.06

0.25

92.3, 100, 83.3

Clarithromycin

0.015 – 2

0.03

0.25

92.3, 100, 83.3

Azithromycin

0.03 – 16

0.12

0.25

92.3, 100, 83.3

Telithromycin

0.008 – 0.12

0.015

0.015

-