Table 4 Enterobacteriaceae isolated from ICU patients during 2000–2002
United States | Canada | Italy | Germany | Francea | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Organism | Agent | Total n | %S | %R | Total n | %S | %R | Total n | %S | %R | Total n | %S | %R | Total n | %S | %R |
Escherichia coli | Cefepime | 10,356 | 98.1 | 1.5 | 207 | 98.1 | 1.9 | 1,426 | 98.1 | 1.4 | 2,830 | 98.6 | 1.2 | 4,358 | 98.9 | 0.6 |
Cefotaxime | 9,086 | 96.5 | 2.2 | 3,231 | 96.3 | 2.5 | 1,748 | 94.5 | 3.8 | 5,828 | 97.8 | 1.8 | 9,362 | 98.8 | 0.6 | |
Ceftazidime | 14,574 | 95.3 | 3.0 | 4,438 | 97.7 | 1.6 | 2,548 | 94.7 | 3.7 | 3,924 | 97.9 | 1.6 | 9,164 | 97.8 | 1.2 | |
Ceftriaxone | 15,897 | 97.4 | 1.7 | 3,829 | 96.8 | 2.2 | 1,423 | 94.4 | 4.2 | 534 | 99.8 | 0.2 | 834 | 98.6 | 1.0 | |
Ciprofloxacin | 17,294 | 89.0 | 10.7 | 5,028 | 90.3 | 9.5 | 2,616 | 87.0 | 12.7 | 4,615 | 86.7 | 12.4 | 8,577 | 93.1 | 6.5 | |
Gentamicin | 20,581 | 92.4 | 6.5 | 6,654 | 92.8 | 5.3 | 2,650 | 92.2 | 6.6 | 4,825 | 94.3 | 5.2 | 9,442 | 95.4 | 4.2 | |
Imipenem | 15,353 | 100 | 0 | 3,386 | 100 | 0 | 2,254 | 100 | 0 | 5,172 | 100 | 0 | 8,994 | 100 | 0 | |
Levofloxacin | 14,920 | 88.2 | 11.6 | 776 | 85.1 | 13.9 | 496 | 86.5 | 13.3 | 3,137 | 88.2 | 11.0 | NTb | NT | NT | |
Piperacillin-tazobactam | 13,573 | 93.1 | 3.6 | 4,305 | 95.1 | 2.4 | 1,879 | 95.8 | 2.4 | 5,637 | 93.6 | 3.4 | 7,255 | 95.4 | 1.1 | |
Trimethoprim-sulfamethoxazole | 20,296 | 79.2 | 20.7 | 6,737 | 84.6 | 15.3 | 2,440 | 75.0 | 24.9 | 5,598 | 73.1 | 26.6 | 9,028 | 78.2 | 21.1 | |
Klebsiella oxytoca | ||||||||||||||||
Cefepime | 1,476 | 96.2 | 3.3 | 19 | 100 | 0 | 255 | 99.6 | 0 | 566 | 96.8 | 2.7 | 478 | 97.1 | 0.4 | |
Cefotaxime | 1,324 | 92.7 | 4.7 | 486 | 94.2 | 4.5 | 230 | 96.5 | 1.7 | 1,117 | 93.8 | 4.4 | 865 | 96.3 | 0.8 | |
Ceftazidime | 1,909 | 91.7 | 7.0 | 661 | 94.9 | 4.1 | 361 | 83.4 | 15.2 | 749 | 95.3 | 4.5 | 870 | 98.3 | 0.5 | |
Ceftriaxone | 2,035 | 89.9 | 6.6 | 536 | 93.8 | 2.8 | 197 | 81.7 | 2.0 | 83 | 97.6 | 0 | 79 | 87.3 | 2.5 | |
Ciprofloxacin | 2,226 | 92.5 | 5.9 | 745 | 96.0 | 3.0 | 368 | 96.7 | 3.0 | 905 | 90.1 | 7.8 | 815 | 94.5 | 4.8 | |
Gentamicin | 2,569 | 89.9 | 8.3 | 857 | 95.0 | 4.9 | 366 | 89.6 | 3.0 | 1,016 | 98.2 | 1.2 | 865 | 97.1 | 2.4 | |
Imipenem | 2,061 | 100 | 0 | 516 | 100 | 0 | 337 | 100 | 0 | 1,062 | 100 | 0 | 845 | 100 | 0 | |
Levofloxacin | 1,754 | 93.3 | 3.4 | 159 | 96.9 | 1.3 | 133 | 97.0 | 3.0 | 560 | 94.6 | 3.2 | NT | NT | NT | |
Piperacillin-tazobactam | 1,801 | 82.7 | 13.9 | 624 | 91.2 | 7.1 | 313 | 81.8 | 11.2 | 1,113 | 78.9 | 18.1 | 742 | 88.3 | 10.4 | |
Trimethoprim-sulfamethoxazole | 2,467 | 92.5 | 7.5 | 863 | 96.3 | 3.6 | 308 | 95.1 | 4.9 | 1,084 | 93.7 | 6.3 | 802 | 94.1 | 5.7 | |
Klebsiella pneumoniae | ||||||||||||||||
Cefepime | 7,276 | 95.8 | 3.4 | 98 | 100 | 0 | 552 | 93.5 | 5.6 | 1,068 | 95.7 | 3.5 | 840 | 95.6 | 3.0 | |
Cefotaxime | 6,243 | 91.0 | 6.1 | 1,411 | 97.9 | 1.5 | 850 | 76.7 | 16.4 | 2,414 | 93.1 | 6.0 | 1,553 | 94.4 | 1.9 | |
Ceftazidime | 9,597 | 88.5 | 10.1 | 2,238 | 97.5 | 2.2 | 1,142 | 69.8 | 28.5 | 1,665 | 90.0 | 8.2 | 1,591 | 92.5 | 5.2 | |
Ceftriaxone | 10,337 | 92.7 | 4.7 | 1,736 | 97.9 | 1.1 | 816 | 75.2 | 15.0 | 166 | 98.8 | 0.6 | 112 | 86.6 | 5.4 | |
Ciprofloxacin | 11,089 | 89.9 | 8.4 | 2,484 | 91.8 | 7.2 | 1,190 | 88.2 | 9.9 | 2,128 | 85.4 | 9.4 | 1,473 | 89.5 | 8.7 | |
Gentamicin | 13,012 | 91.6 | 7.0 | 2,906 | 96.7 | 2.9 | 1,211 | 81.4 | 14.5 | 2,065 | 91.6 | 6.1 | 1,553 | 97.1 | 2.7 | |
Imipenem | 10,263 | 100 | 0 | 1,766 | 100 | 0 | 1,066 | 100 | 0 | 2,351 | 100 | 0 | 1,567 | 100 | 0 | |
Levofloxacin | 9,626 | 91.0 | 6.4 | 485 | 93.4 | 3.7 | 287 | 78.4 | 21.3 | 1,228 | 92.6 | 4.4 | NT | NT | NT | |
Piperacillin-tazobactam | 9,359 | 85.9 | 7.4 | 2,160 | 91.5 | 2.7 | 746 | 82.2 | 14.6 | 2,408 | 84.9 | 8.3 | 1,286 | 89.4 | 5.1 | |
Trimethoprim-sulfamethoxazole | 12,641 | 88.6 | 11.1 | 2,924 | 92.8 | 7.1 | 1,103 | 82.0 | 18.0 | 2,324 | 82.2 | 17.2 | 1,443 | 88.2 | 10.9 | |
Morganella morganii | ||||||||||||||||
Cefepime | 566 | 95.9 | 2.3 | <10 | NA | NA | 121 | 97.5 | 2.5 | 262 | 94.7 | 5.0 | 412 | 96.1 | 0.2 | |
Cefotaxime | 499 | 78.8 | 8.4 | 156 | 91.0 | 3.8 | 144 | 74.3 | 6.3 | 437 | 86.7 | 3.9 | 678 | 81.1 | 5.9 | |
Ceftazidime | 715 | 73.6 | 17.3 | 256 | 79.7 | 10.9 | 213 | 75.6 | 15.0 | 313 | 84.0 | 7.7 | 673 | 78.6 | 8.0 | |
Ceftriaxone | 806 | 91.1 | 2.2 | 219 | 96.3 | 1.4 | 125 | 91.2 | 3.2 | 22 | 86.4 | 0 | 57 | 84.2 | 5.3 | |
Ciprofloxacin | 841 | 78.1 | 20.7 | 292 | 94.2 | 4.5 | 220 | 87.3 | 9.5 | 344 | 97.7 | 2.0 | 634 | 88.6 | 8.5 | |
Gentamicin | 967 | 84.0 | 14.1 | 329 | 94.5 | 4.6 | 222 | 90.1 | 8.6 | 378 | 96.8 | 2.1 | 679 | 95.6 | 3.4 | |
Imipenem | 784 | 100 | 0 | 196 | 100 | 0 | 206 | 100 | 0 | 402 | 100 | 0 | 649 | 99.8 | 0 | |
Levofloxacin | 725 | 78.1 | 19.3 | 42 | 95.2 | 4.8 | 55 | 90.9 | 9.1 | 251 | 98.0 | 1.6 | NT | NT | NT | |
Piperacillin-tazobactam | 725 | 91.2 | 5.1 | 254 | 97.2 | 1.6 | 150 | 94.0 | 3.3 | 430 | 94.2 | 3.5 | 564 | 91.0 | 4.6 | |
Trimethoprim-sulfamethoxazole | 936 | 75.1 | 24.7 | 329 | 91.8 | 8.2 | 193 | 79.8 | 20.2 | 435 | 93.1 | 6.9 | 627 | 83.9 | 14.2 | |
Proteus mirabilis | ||||||||||||||||
Cefepime | 1,964 | 98.2 | 1.0 | 20 | 100 | 0 | 395 | 87.6 | 11.4 | 599 | 99.2 | 0.8 | 736 | 99.0 | 0.1 | |
Cefotaxime | 1,794 | 99.1 | 0.5 | 295 | 99.7 | 0 | 441 | 69.4 | 23.4 | 1,209 | 98.8 | 0.7 | 1,503 | 99.5 | 0.1 | |
Ceftazidime | 2,684 | 98.0 | 1.1 | 463 | 99.4 | 0.2 | 630 | 86.0 | 9.4 | 821 | 98.5 | 1.0 | 1,505 | 99.3 | 0.2 | |
Ceftriaxone | 3,034 | 99.4 | 0.3 | 392 | 99.5 | 0 | 385 | 80.5 | 13.8 | 77 | 98.7 | 0 | 72 | 100 | 0 | |
Ciprofloxacin | 3,169 | 85.2 | 12.7 | 504 | 95.2 | 4.6 | 657 | 70.6 | 22.7 | 980 | 92.9 | 5.1 | 1,424 | 90.9 | 6.8 | |
Gentamicin | 3,796 | 91.5 | 7.7 | 698 | 92.6 | 7.2 | 670 | 61.6 | 37.2 | 992 | 92.9 | 5.9 | 1,509 | 91.3 | 7.9 | |
Imipenem | 2,850 | 100 | 0 | 367 | 100 | 0 | 580 | 100 | 0 | 1,020 | 100 | 0 | 1,319 | 100 | 0 | |
Levofloxacin | 2,825 | 87.8 | 10.5 | 94 | 100 | 0 | 202 | 61.9 | 34.7 | 688 | 96.5 | 2.3 | <10 | NAc | NA | |
Piperacillin-tazobactam | 2,715 | 97.7 | 0.8 | 449 | 98.2 | 0.2 | 465 | 95.7 | 2.8 | 1,201 | 98.6 | 0.8 | 1,231 | 99.3 | 0.2 | |
Trimethoprim-sulfamethoxazole | 3,706 | 85.2 | 14.7 | 708 | 89.4 | 10.6 | 615 | 61.6 | 38.0 | 1,159 | 80.8 | 19.1 | 1,411 | 79.7 | 18.6 | |
Serratia marcescens | ||||||||||||||||
Cefepime | 3,653 | 96.7 | 2.3 | 52 | 96.2 | 1.9 | 497 | 96.8 | 2.2 | 546 | 94.1 | 3.5 | 509 | 98.6 | 0.2 | |
Cefotaxime | 3,134 | 87.0 | 5.7 | 670 | 92.8 | 2.7 | 470 | 79.6 | 9.8 | 951 | 84.0 | 7.5 | 809 | 81.5 | 3.3 | |
Ceftazidime | 4,718 | 89.7 | 7.9 | 1,113 | 95.2 | 3.0 | 738 | 81.4 | 13.3 | 851 | 89.7 | 7.5 | 812 | 94.7 | 3.0 | |
Ceftriaxone | 4,710 | 90.5 | 4.6 | 846 | 95.4 | 1.7 | 444 | 86.7 | 6.3 | 160 | 45.6 | 0 | 115 | 77.4 | 4.3 | |
Ciprofloxacin | 5,006 | 91.0 | 6.7 | 1,292 | 85.0 | 11.7 | 757 | 83.5 | 4.5 | 978 | 72.6 | 12.4 | 787 | 78.9 | 10.5 | |
Gentamicin | 5,905 | 92.9 | 5.9 | 1,313 | 94.6 | 5.2 | 758 | 97.4 | 2.1 | 665 | 92.9 | 6.3 | 808 | 91.6 | 6.6 | |
Imipenem | 4,960 | 100 | 0 | 880 | 100 | 0 | 727 | 100 | 0 | 1,018 | 100 | 0 | 805 | 100 | 0 | |
Levofloxacin | 4,356 | 94.3 | 4.2 | 264 | 92.4 | 4.2 | 266 | 95.5 | 1.5 | 595 | 87.6 | 6.6 | <10 | NA | NA | |
Piperacillin-tazobactam | 4,337 | 88.1 | 5.1 | 1,155 | 91.6 | 3.3 | 547 | 92.7 | 3.8 | 1,053 | 77.6 | 3.1 | 749 | 82.6 | 2.4 | |
Trimethoprim-sulfamethoxazole | 5,697 | 95.9 | 3.9 | 1,325 | 94.9 | 5.1 | 646 | 81.4 | 18.6 | 908 | 88.1 | 10.9 | 699 | 84.1 | 13.6 | |