Table 3 S. pneumoniae, S. pyogenes, S. agalactiae, and Viridans group streptococci isolated from ICU patients during 2000–2002
United States | Canada | Italy | Germany | Francea | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Organism | Agent | Total n | %S | %R | Total n | %S | %R | Total n | %S | %R | Total n | %S | %R | Total n | %S | %R |
Streptococcus pneumoniae | Amoxicillin | 120 | 91.7 | 2.5 | 31 | 100 | 0 | 60 | 93.3 | 6.7 | 17 | 100 | 0 | 1,328 | 71.2 | 2.3 |
Cefepime | 22 | 90.9 | 4.5 | 25 | 60.0 | 12.0 | 66 | 90.9 | 7.6 | NTb | NT | NT | <10 | NAc | NA | |
Cefotaxime | 1,571 | 82.2 | 6.3 | 145 | 93.8 | 0.7 | 108 | 93.5 | 4.6 | 63 | 100 | 0 | 1,181 | 77.1 | 0.8 | |
Ceftriaxone | 2,373 | 88.3 | 3.2 | 145 | 91.7 | 0.7 | 145 | 91.7 | 3.4 | 29 | 100 | 0 | 544 | 80.1 | 0.6 | |
Clarithromycin | 184 | 71.7 | 25.5 | 56 | 69.6 | 30.4 | 90 | 64.4 | 31.1 | <10 | NA | NA | NT | NT | NT | |
Erythromycin | 3,029 | 67.9 | 30.5 | 539 | 78.5 | 20.8 | 313 | 69.6 | 28.1 | 405 | 88.6 | 9.4 | 1,567 | 59.0 | 38.8 | |
Levofloxacin | 2,133 | 99.1 | 0.4 | 356 | 98.6 | 1.1 | 174 | 98.3 | 0.6 | 340 | 99.4 | 0.3 | 62 | 98.4 | 1.6 | |
Penicillin | 3,096 | 51.5 | 20.2 | 325 | 59.1 | 7.1 | 198 | 77.3 | 7.6 | 102 | 96.1 | 2.0 | 1,387 | 45.5 | 17.9 | |
Vancomycin | 2,865 | 100 | -c | 271 | 100 | - | 231 | 100 | - | 190 | 100 | - | 1,479 | 100 | - | |
Streptococcus pyogenes | ||||||||||||||||
Amoxicillin | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | 58 | 100 | 0 | |
Cefepime | <10 | NA | NA | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | |
Cefotaxime | 32 | 100 | - | 29 | 100 | - | <10 | NA | NA | 11 | 100 | - | 30 | 100 | - | |
Ceftriaxone | 75 | 100 | - | <10 | NA | NA | <10 | NA | NA | <10 | NA | NA | <10 | NA | NA | |
Clarithromycin | 19 | 84.2 | 5.3 | <10 | NA | NA | 17 | 88.2 | 11.8 | NT | NT | NT | NT | NT | NT | |
Erythromycin | 118 | 92.4 | 6.8 | 102 | 81.4 | 11.8 | 59 | 74.6 | 23.7 | 63 | 84.1 | 11.1 | 170 | 82.9 | 14.7 | |
Levofloxacin | 71 | 97.2 | 1.4 | <10 | NA | NA | <10 | NA | NA | 61 | 77.0 | 4.9 | NT | NT | NT | |
Penicillin | 140 | 100 | - | 97 | 100 | - | 58 | 100 | - | 64 | 100 | - | 139 | 100 | - | |
Vancomycin | 121 | 100 | - | 42 | 100 | - | 12 | 100 | - | 34 | 100 | - | 162 | 100 | - | |
Streptococcus agalactiae | ||||||||||||||||
Amoxicillin | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | 165 | 100 | 0 | |
Cefepime | 28 | 100 | - | NT | NT | NT | <10 | NA | NA | NT | NT | NT | NT | NT | NT | |
Cefotaxime | 71 | 100 | - | 17 | 100 | - | 24 | 100 | - | 50 | 100 | - | 50 | 100 | - | |
Ceftriaxone | 184 | 100 | - | <10 | NA | NA | 38 | 100 | - | 37 | 100 | - | <10 | NA | NA | |
Clarithromycin | 21 | 81.0 | 9.5 | <10 | NA | NA | 21 | 71.4 | 28.6 | NT | NT | NT | <10 | NA | NA | |
Erythromycin | 489 | 76.3 | 21.7 | 222 | 82.9 | 14.9 | 121 | 77.7 | 18.2 | 192 | 83.9 | 10.9 | 588 | 79.9 | 16.2 | |
Levofloxacin | 333 | 97.9 | 1.2 | <10 | NA | NA | 51 | 98.0 | 0 | 180 | 91.1 | 1.7 | 173 | 99.4 | 0 | |
Penicillin | 518 | 100 | - | 226 | 100 | - | 145 | 100 | - | 184 | 100 | - | 369 | 100 | - | |
Vancomycin | 463 | 100 | - | 179 | 100 | - | 143 | 100 | - | 65 | 100 | - | 526 | 100 | - | |
Streptococcus viridans group | ||||||||||||||||
Amoxicillin | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | 268 | 92.9 | 0.7 | |
Cefepime | 23 | 95.7 | 4.3 | NT | NT | NT | 12 | 66.7 | 33.3 | NT | NT | NT | NT | NT | NT | |
Cefotaxime | 434 | 83.6 | 11.1 | 101 | 92.1 | 4.0 | 31 | 90.3 | 9.7 | 75 | 97.3 | 2.7 | 56 | 94.6 | 0 | |
Ceftriaxone | 678 | 87.3 | 7.7 | 130 | 89.2 | 3.8 | 99 | 81.8 | 18.2 | 40 | 97.5 | 2.5 | <10 | NA | NA | |
Clarithromycin | 34 | 52.9 | 38.2 | 21 | 76.2 | 19.0 | 21 | 71.4 | 23.8 | <10 | NA | NA | NT | NT | NT | |
Erythromycin | 959 | 57.2 | 37.7 | 289 | 71.6 | 23.2 | 192 | 64.6 | 32.8 | 796 | 88.1 | 9.2 | 626 | 59.9 | 31.6 | |
Levofloxacin | 331 | 96.1 | 2.7 | <10 | NA | NA | 16 | 87.5 | 0 | 93 | 89.2 | 4.3 | <10 | NA | NA | |
Penicillin | 1,047 | 63.7 | 6.2 | 303 | 79.2 | 0 | 61 | 78.7 | 8.2 | <10 | NA | NA | 452 | 69.0 | 3.1 | |
Vancomycin | 1,095 | 100 | - | 276 | 100 | - | 180 | 100 | - | 277 | 100 | - | 580 | 100 | - | |