A second-generation anti TB vaccine is long overdue

Table 1 Listing of gene and antigen differences presented in Mycobacterium bovis BCG daughter strains. The data was taken from research and historical reports. Genetic and phenotypic differences of M. bovis BCG daughter strains.

STRAIN	SYNONIMOUS	DELETIONS (ORF's)	MPB64	MPB70	Methoxymycolic acid's	EXOCHELIN'S μg/ml
PASTEUR		DR1, DR2, DR14 (28)	P	LOW	N	345
PHIPPS	PHILADELPHIA	DR1, DR2 (20)	P	LOW	N	ND
FRAPPIER	MONTREAL	DR1, DR2, DR8 (24)	P	LOW	N	ND
CONNAUGHT	TORONTO	DR1, DR2, DR8 (24)	P	LOW	N	ND
TICE	CHICAGO	DR1, DR2 (20)	P	LOW	N	390
DENMARK	DANISH 1331	DR1, DR2 (20)	P	LOW	N	140
GLAXO		DR1, DR2 (20)	P	LOW	N	75
PRAGUE		DR1, DR2 (20)	P	LOW	N	ND
BIRKHAUG		DR1, DR2 (20)	P	LOW	N	ND
SWEDEN	GHOTHENBURG	DR1 (9)	N	HIGH	P	ND
JAPAN	TOKYO	DR1 (9)	N	HIGH	P	150
MOREAU	BRAZIL	DR1, DR 16 (15)	N	HIGH	P	ND
RUSSIA	MOSCOW	DR1 (9)	N	HIGH	P	ND
MEXICO		DR1, DR2 (20)	P	LOW	N	ND

DR: Deleted Regions, ORF: Open Reading Frame, P: Protein or antigen expression, N: Non protein or antigen expression, ND: Non determinate.

ISSN: 1476-0711