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Table 2 Results of the second phase of the animal study

From: The effect of indomethacin, myeloperoxidase, and certain steroid hormones on bactericidal activity: an ex vivo and in vivo experimental study

  1. N0 2. NT 3. C0 4. CT 5. CE p < 0.05
Castrated No No Yes Yes Yes  
Treatment None Testosterone None Testosterone Estradiol  
Infection Yes Yes Yes Yes Yes  
Colony patterns: Heart blood Liver Heart blood Liver Heart blood Liver Heart blood Liver Heart blood Liver  
None 0 2 1 1 1 1 1 1 1 0  
1-10 colonies 2 1 4 3 2 1 0 0 4 3  
Dense, but separate 2 2 0 2 0 2 1 2 1 3  
Confluent 2 1 1 0 2 1 4 3 0 0  
Sample number for lab tests 6 6 5 6 5  
WBC (×109/l) 10.70 ± 4.18 5.97 ± 3.22 8.26 ± 4.62 3.61 ± 2.14 2.03 ± 1.05 1 vs 4,5
Neutrophil (%) 50.02 ± 21.82 54.30 ± 26.95 54.12 ± 19.20 38.40 ± 26.29 53.15 ± 21.23 ns
Lymphocyte (%) 45.20 ± 22.89 37.46 ± 28.09 39.56 ± 16.32 58.22 ± 23.98 41.15 ± 22.52 ns
RBC (×1012/l) 6.63 ± 0.32 6.44 ± 0.45 5.99 ± 0.47 5.41 ± 0.86 5.95 ± 0.21 4 vs 1,2
HGB (g/dl) 135.40 ± 4.67 132.40 ± 7.16 120.60 ± 12.46 111.40 ± 16.68 120.75 ± 4.65 4 vs 1,2
HCT (l/l) 0.41 ± 0.02 0.40 ± 0.03 0.36 ± 0.03 0.32 ± 0.05 0.35 ± 0.02 4 vs 1,2; 5 vs 1
PLT (×109/l) 718.80 ± 298.45 865.40 ± 212.51 875.60 ± 170.04 696.60 ± 127.91 440.75 ± 198.01 5 vs 2,3
Total protein (g/l) 47.32 ± 2.02 49.53 ± 2.88 51.00 ± 4.45 46.83 ± 4.24 49.76 ± 3.71 ns
Albumin (g/l) 16.68 ± 1.17 17.55 ± 1.18 18.30 ± 1.59 17.03 ± 2.14 18.76 ± 1.50 ns
Globulin (g/l) 30.63 ± 2.67 31.98 ± 2.18 32.70 ± 4.67 29.80 ± 3.03 31.00 ± 2.53 ns
CRP (mg/dl) 375.30 ± 64.54 371.58 ± 33.56 363.30 ± 23.90 329.42 ± 52.21 149.60 ± 131.71 5 vs 1,2,3,4
Testosterone (nmol/l) 21.62 ± 16.08 54.87 ± 1.55 0.87 ± 0.31 41.82 ± 12.10 0.68 ± 0.00 1 vs 2,3,4,5; 2 vs 3,5; 4 vs 3,5
Estradiol (pg/ml) 113.44 ± 30.62 nd 151.75 ± 13.12 nd 867.40 ± 558.15 5 vs 1,3
  1. The number of different P. multocida colony shapes and laboratory results (means ± SD). The last column shows the groups where significant differences were found. ns: not significant, nd: not determined.