Table 1 Results of the first phase of the animal study

Treatment

None (methylcellulose)

Indomethacin

None (methylcellulose)

Indomethacin

Infection

No

No

Yes

Yes

Colony patterns:

Heart blood

Liver

Heart blood

Liver

None

2

1

0

0

1-10 colonies

3

2

2

1

Dense, but separate

1

4

1

1

Confluent

2

1

5

6

Sample number for lab tests

6

5

6

7

WBC (×10⁹/l)

7.72 ± 2.06

5.09 ± 3.53

5.95 ± 2.61

9.28 ± 1.87

4 vs 2,3

Neutrophil (%)

18.00 ± 4.53

47.40 ± 26.10

22.83 ± 5.64

30.83 ± 9.30

ns

Lymphocyte (%)

80.00 ± 4.36

49.00 ± 28.10

73.67 ± 6.47

64.50 ± 9.22

ns

RBC (×10¹²/l)

5.94 ± 0.68

3.86 ± 1.52

5.66 ± 0.39

3.66 ± 1.09

4 vs 1

HGB (g/dl)

110.00 ± 9.00

73.40 ± 29.20

105.67 ± 6.83

68.50 ± 18.22

4 vs 1

HCT (l/l)

0.39 ± 0.03

0.26 ± 0.11

0.38 ± 0.03

0.25 ± 0.07

4 vs 1

Total protein (g/l)

55.65 ± 2.49

52.20 ± 4.65

59.22 ± 3.00

42.00 ± 7.86

4 vs 3

Albumin (g/l)

27.92 ± 0.98

22.88 ± 3.13

26.07 ± 0.65

19.80 ± 3.65

4 vs 1

Globulin (g/l)

27.73 ± 1.63

29.32 ± 2.79

33.15 ± 2.63

22.20 ± 4.30

3 vs 1,2,4; 4 vs 1,2

CRP (mg/dl)

300.00 ± 25.20

306.60 ± 32.90

411.67 ± 55.98

261.71 ± 72.99

3 vs 1,2,4