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Table 2 Minimum inhibitory concentrations (MICs) of new naphthoquinones against different fungal species

From: Antifungal activity of synthetic naphthoquinones against dermatophytes and opportunistic fungi: preliminary mechanism-of-action tests

Group microorganism

Culture (n = 89)

Nor-alfa

Nor-beta

IVS320

IVS322

ketoconazole

Minimum Inhibitory Concentration (MIC) μg/mL

  

GM

Range

GM

Range

GM

Range

GM

Range

GM

Range

Yeasts opportunistic

C. albicans (n = 10)

66

6.3 – 100

86

6.3 – 100

35

3.1-50

78

6,3-100

1

0,125-2

C. parapsilosis (n = 10)

50

-

75

25-100

25

13-50

86

25-100

0,06

-

C. neoformans (n = 05)

15

12.5-50

100

100

5

1,56-6,25

56

25-50

-

-

C. gattii (n = 04)

25

12.5-50

100

100

3

1,56-6.25

44

25-50

-

-

Dermatophytes

T. rubrum (n = 10)

16

6.3-25

19

6.3-100

5

3,3-12,5

10

6,3-25

29

2-64

M. canis (n = 10)

43

25-50

30

12,5-100

8

3,1-12,5

24

3,1-100

5

1-16

M. gypseum (n = 10)

78

50-100

67

25-100

28

12,5-50

122

50-200

5

2-8

T. tonsurans (n = 10)

35

12,5-50

34

6.3-200

8

3,11-25

38

25-50

1

0,5-4

Filamentous opportunistic

Fusarium sp. (n = 10)

117

50-200

67

25-100

36

25-50

103

50-200

6

1-16

 

Aspergillus sp. (n = 10)

90

50-100

75

50-100

33

6,3-50

85

50-100

32

4-64

  1. GM = geometric mean; − test not performed, n = number of different isolates.
  2. The geometric mean and range for each compound against each group of fungal species are reported.