Table 1 Antimicrobial resistance profiles and resistance (R)-encoding genes of S. epidermidis isolates collected from healthcare workers (HCWs; n =42) vs. S. epidermidis isolates causing catheter-related bloodstream infections (CRBSIs; n = 20)
Antimicrobial | Encoding gene | HCWs (% R) | CRBSIs (% R) | P-value |
|---|---|---|---|---|
Penicillin | 37 (88%) | 20 (100%) | 0.165 | |
Methicillin (cefoxitin) | 26 (62%) | 17 (85%) | 0.065 | |
mecA | 26 | 17 | 0.065 | |
Erythromycin | 26 (62%) | 15 (75%) | 0.308 | |
ermC | 11 | 12 | 0.009 | |
msrA | 13 | 0 | 0.006 | |
ermA | 1 | 3 | 0.034 | |
Clindamycin | 14 [6]* (33%) | 15 [5]* (75%) | 0.002 | |
Levofloxacin | 10 (24%) | 14 (70%) | < 0.001 | |
Fusidic acid | 19 (45%) | 13 (65%) | 0.146 | |
Trimethoprim/sulfamethoxazole | 4 (10%) | 11 (55%) | < 0.001 | |
Aminoglycosides§ (at least one) | 10 (24%) | 13 (65%) | 0.002 | |
Kanamycin | 9 (21%) | 13 (65%) | < 0.001 | |
Tobramycin | 6 (14%) | 13 (65%) | < 0.001 | |
Gentamicin | 5 (12%) | 10 (50%) | 0.003 | |
aadC | 6 | 11 | < 0.001 | |
aacA-aphD | 5 | 10 | 0.003 | |
aph3 | 3 | 1 | 1.000 | |
Mupirocin | 4 (10%) | 8 (40%) | 0.013 | |
Rifampin | 0 (0%) | 5 (25%) | 0.002 | |
Median sum of resistance to non-beta-lactams (range) | 2 (0–5) | 5 (0–8) | < 0.001 |